Adults 18 to 80, any sex, with Stroke or Stroke, Acute. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change in Postural Assessment Stroke Scale (PASS)Primary· From date of PT evaluation up until 90 day stroke follow up post hospital discharge
The scale measures 12 items of balance in sitting, lying and standing with increasing amounts of difficulty. It consists of a 4 point scale, measured from 0 to 3 with scores that range from 0-36. Patients with a lower score have a more severe impairment, and patients with a higher score have a less severe impairment.
Initial Eval
Group
Value
95% CI
Standard of Care PT
19.64
± 8.68
Frequent PT Services
19.86
± 7
Error Augmentation Training
19.25
± 8.86
Frequent Intense PT
23.21
± 7.32
Day 3
Group
Value
95% CI
Standard of Care PT
22.95
± 9.83
Frequent PT Services
27
± 6.26
Error Augmentation Training
23.90
± 8.83
Frequent Intense PT
29.10
± 7
Discharge
Group
Value
95% CI
Standard of Care PT
25.86
± 8.68
Frequent PT Services
28.95
± 5.52
Error Augmentation Training
27.74
± 7.72
Frequent Intense PT
32.17
± 5.08
30-Day
Group
Value
95% CI
Standard of Care PT
28.78
± 10.79
Frequent PT Services
31.38
± 5.45
Error Augmentation Training
31.75
± 6.99
Frequent Intense PT
33.68
± 5.71
Change in Activity Measure for Post Acute Care (AM-PAC)Primary· From date of PT evaluation up until 90 day stroke follow up post hospital discharge
The scale measures basic mobility in the hospital setting including moving around in bed, getting out of bed, sitting and standing, moving from a bed to a chair, walking, and going up and down stairs. It consists of a 4 point scale measured from 1 to 4 with scores that range from 6 to 24. Patients with a lower score have a more severe impairment, and patients with a higher score have a less severe impairment.
Initial Eval
Group
Value
95% CI
Standard of Care PT
15.32
± 4.49
Frequent PT Services
15.32
± 3.96
Error Augmentation Training
14.79
± 4.33
Frequent Intense PT
16.83
± 3.47
Day 3
Group
Value
95% CI
Standard of Care PT
17.32
± 5.10
Frequent PT Services
19.26
± 3.68
Error Augmentation Training
17.20
± 4.94
Frequent Intense PT
19.85
± 3.83
Discharge
Group
Value
95% CI
Standard of Care PT
18.95
± 4.98
Frequent PT Services
20.32
± 3.37
Error Augmentation Training
19.25
± 4.80
Frequent Intense PT
22.0
± 2.78
30-Day
Group
Value
95% CI
Standard of Care PT
21.41
± 4.99
Frequent PT Services
21.75
± 3.79
Error Augmentation Training
22.81
± 2.2
Frequent Intense PT
23.0
± 3.13
Patient's Modified Rankin Scale (mRS) Post Acute StrokeSecondary· On date of PT evaluation
The scale is a questionnaire that asks patients about their ability to perform activities of daily living (ADL's) taking into account their physical, mental, and speech performance. On admission the questionnaire focuses on their ability to perform ADL's prior to their stroke. At discharge and at 90 day follow up the questionnaire focuses on their ability to perform ADL's at that time point. It is scored from 0 to 5. Patients with a lower score have a less severe impairment, and patients with a higher score have a more severe impairment.
No symptoms
Group
Value
95% CI
Standard of Care PT
0
Frequent PT Services
0
Error Augmentation Training
0
Frequent Intense PT
0
No disability despite symptoms
Group
Value
95% CI
Standard of Care PT
1
Frequent PT Services
2
Error Augmentation Training
3
Frequent Intense PT
2
Slight disability
Group
Value
95% CI
Standard of Care PT
2
Frequent PT Services
3
Error Augmentation Training
2
Frequent Intense PT
4
Moderate Disability
Group
Value
95% CI
Standard of Care PT
2
Frequent PT Services
2
Error Augmentation Training
3
Frequent Intense PT
6
Moderate/Severe Disability
Group
Value
95% CI
Standard of Care PT
16
Frequent PT Services
13
Error Augmentation Training
15
Frequent Intense PT
12
Severe Disability
Group
Value
95% CI
Standard of Care PT
1
Frequent PT Services
2
Error Augmentation Training
1
Frequent Intense PT
0
Change in National Institute of Health Stroke Scale Score (NIHSS)Secondary· From date of PT evaluation up until 30 day stroke follow up post hospital discharge
The scale measures the severity of symptoms associated with patient's stroke. It assesses the severity of impairments related to stroke. The impairments are graded on a 3-4 point scale with scores that range from 0-42. Patients with a higher score have a more severe impairment, and patients with a lower score have a less severe impairment.
Initial Eval
Group
Value
95% CI
Standard of Care PT
8.4
± 5.15
Frequent PT Services
7.38
± 5.18
Error Augmentation Training
7.25
± 4.11
Frequent Intense PT
7.13
± 4.39
Day 3
Group
Value
95% CI
Standard of Care PT
6.11
± 5.57
Frequent PT Services
5.84
± 4.14
Error Augmentation Training
5.63
± 5.11
Frequent Intense PT
4
± 3.2
Discharge
Group
Value
95% CI
Standard of Care PT
3.95
± 3.71
Frequent PT Services
4
± 3.49
Error Augmentation Training
4.58
± 4.38
Frequent Intense PT
2.36
± 2.5
30-Day
Group
Value
95% CI
Standard of Care PT
3.11
± 4.44
Frequent PT Services
2.73
± 2.63
Error Augmentation Training
2.27
± 3.58
Frequent Intense PT
1.58
± 2.67
Length of StaySecondary· From day of hospital admission to day of hospital discharge, measured in days; up to 30 days.
Average hospitalization (measured in days)
Group
Value
95% CI
Standard of Care PT
6.20
± 3.3
Frequent PT Services
6.09
± 4.97
Error Augmentation Training
6.75
± 4.72
Frequent Intense PT
5.96
± 3.61
Adverse events — posted to ClinicalTrials.gov
Time frame: Hospital admission to 30 days post discharge..
Reporting threshold: 2%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
The Department of Physical Therapy in conjunction with the Comprehensive Stroke Center at the Medical University of South Carolina (MUSC) seeks support for developing an evidence-based approach for the mobilization of patients within the first 24 hours of admission for an acute stroke and for increasing the frequency and intensity of acute PT services while inpatient. This evidence will prepare physical therapists and guide practice in the delivery of acute stroke mobilization in the hospital setting to optimize length of stay, disposition planning, and enhance long term recovery outcomes.
This research hopes to challenge the clinical paradigm regarding the possibility of decreased functional outcomes with early mobilization post stroke. The investigators acknowledge that acute stroke patients may not be able to tolerate an extensive early mobility program but may benefit from shorter more frequent sessions of therapy early in their recovery. Throughout the literature, there are clinical practice guidelines for both the inpatient rehabilitation and outpatient therapy sectors and post stroke recovery. Little is known about the contribution of therapy services in the acute hospital setting and therapy's impact on long term functional gains. This study will compare outcomes (AM-PAC, PASS, length of stay and post discharge mRS) across four groups- 1) standard of care 2) increased frequency 3) increased intensity 4) combined increased frequency and intensity. The goal of this project is to determine the appropriate dosage of post stroke mobility in the acute care hospital setting.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Sponsor: as reported to ClinicalTrials.gov by Medical University of South Carolina
Last refreshed: 25 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06042179.