18 and older, any sex, with Weight Loss or Obesity. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change in Weight in Pounds From Week 0 to Week 24Primary· 0 to 24 weeks
Effect of WW GLP1 behavioral program + WW Clinic (formerly known as Sequence) on absolute change of weight loss at 24 weeks.
Group
Value
95% CI
Single Arm
-27.41
± 14.86
Weight Loss Percentage Change From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on weight loss and % reaching 5, 10, 15, 20 % body weight loss at 24 weeks.
Number of participants with >= 5% weight loss at 24 weeks
Group
Value
95% CI
Single Arm
161
Number of participants with >= 10% weight loss at 24 weeks
Group
Value
95% CI
Single Arm
121
Number of participants with >= 15% weight loss at 24 weeks
Group
Value
95% CI
Single Arm
81
Number of participants with >= 20% weight loss at 24 weeks
Group
Value
95% CI
Single Arm
20
Blood Pressure Changes (Systolic and Diastolic) in mmHg From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of blood pressure at 24 weeks
Change in diastolic blood pressure at 24 weeks
Group
Value
95% CI
Single Arm
-5.66
± 13.29
Change in systolic blood pressure at 24 weeks
Group
Value
95% CI
Single Arm
-11.17
± 14.96
Change in Quality of Life Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Quality of Life (QOL) scores using "Impact of Weight on Quality of Life-Lite Scale" Scale Name + Description of scale: "Impact of Weight on Quality of Life-Lite (IWQOL-Lite) Is a validated, 31-item, self-report measure of obesity-specific quality of life in adults. There are five domains include physical function, self-esteem, sexual life, public distress and work.
Scale Ranges (min, max): 0-100 Description of scoring: Higher scores represent lower quality of life (i.e., greater impact of obesity on quality of life).
Physical Function
Group
Value
95% CI
Single Arm
-20.13
± 17.79
Self-Esteem
Group
Value
95% CI
Single Arm
-27.98
± 22.5
Sexual Life
Group
Value
95% CI
Single Arm
-18.27
± 23.1
Public Distress
Group
Value
95% CI
Single Arm
-11.44
± 17.99
Work
Group
Value
95% CI
Single Arm
-12.08
± 19.81
Total Score
Group
Value
95% CI
Single Arm
-19.19
± 13.42
Changes in Well-being Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Well-being at 24 weeks using "WHO Well-Being Index 5" Scale Name + Description of scale: "Well-being Index 5 (WHO-5)" is a 5-item questionnaire that assesses subjective well-being through five statements about feeling cheerful, calm, active, interested and rested over the past two weeks.
Scale Ranges (min, max) 0-25 Description of scoring: Lower scores indicate worse overall well-being, higher scores indicate better overall well-being. A positive mean change indicates improvement in well-being.
Group
Value
95% CI
Single Arm
2.92
± 3.98
Changes in Disordered Eating Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Disordered Eating at 24 weeks using "Eating Disorder Examination-Questionnaire" Scale Name + Description of scale: "Eating Disorder Examination-Questionnaire (EDE-Q)" is a 28-item self-report questionnaire, adapted from the semi-structured interview, the Eating Disorder Examination (EDE). The questionnaire is designed to assess the range, frequency and severity of behaviors associated with a diagnosis of an eating disorder.
Scale Ranges (min, max): 0-6 Description of scoring: Lower scores indicate less problematic eat
Restraint Score
Group
Value
95% CI
Single Arm
0.09
± 1.74
Eating Concerns Score
Group
Value
95% CI
Single Arm
-0.75
± 1.28
Shape Concern Score
Group
Value
95% CI
Single Arm
-1.04
± 1.07
Weight Concern Score
Group
Value
95% CI
Single Arm
-0.76
± 0.8
Global Score
Group
Value
95% CI
Single Arm
-0.61
± 0.95
Changes in Strength Training Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Strength Training Behavior at 24 weeks using the "Strength Training Behavior Scale" Scale Name + Description of scale: "Stage of Change for Strength Training" Strength training is defined as all activities that serve to enhance muscle strength and endurance (free weights, body weight exercises, etc.) Regular resistance training is described as engaging in these activities at least two times per week.
Scale Ranges (min, max): 0-7 Description of scoring: Lower scores indicate less days strength training. Higher scores e
Group
Value
95% CI
Single Arm
0.48
± 1.37
Changes in Stress Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Stress at 24 weeks using the "Perceived Stress Scale" Scale Name + Description of scale: "Perceived Stress Scale, PSS-10" is a self-report scale that asks about feelings and thoughts related to stressful things during the last month.
Scale Ranges (min, max): 10-50 Description of scoring: Higher scores indicate more perceived stress and lower scores indicate less perceived stress. A negative mean change indicates improvement in perceived stress.
Group
Value
95% CI
Single Arm
-2.66
± 6.51
Changes in Emotional Eating Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Emotional Eating scores using the "Palatable Eating Motives Scale-Coping Subscale" Scale Name + Description of scale: "Palatable Eating Motives Scale - Coping Subscale (PEMs-Coping)" is a four-item coping subscale of the PEMs self-report that measures eating behavior as a method of coping with problems and negative feelings.
Scale Ranges (min, max): 4-20 Description of scoring: Lower scores indicate lower frequency of eating as a method of coping with problems and negative feelings. Higher scores indicate higher frequ
Group
Value
95% CI
Single Arm
-3.99
± 4.79
Changes in UnHealthy Habits Strength Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Unhealthy Habits scores using "Self-Reported Behavioral Automaticity Index" Scale Name + Description of scale: "Self-Reported Behavioral Automaticity Index (SRBAI)-Unhealthy Habits Subscale" is a self-report measure to assess how automatic or habitual certain behaviors are, often used to understand unhealthy habits. Unhealthy habits included are eating sugary foods, fried foods and drinking sugary drinks.
Scale Ranges (min, max): 1-7 Description of scoring: Lower scores indicate less automatic or habitual unhealthy ha
Sugary Foods
Group
Value
95% CI
Single Arm
-1.64
± 1.86
Fried Foods
Group
Value
95% CI
Single Arm
-1.13
± 1.81
Drinking
Group
Value
95% CI
Single Arm
-0.83
± 1.66
Changes in Healthy Habits Strength Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Habit Strength scores using the "Self-Reported Behavioral Automaticity Index for Healthy Habits" Scale Name + Description of scale: "Self-Reported Behavioral Automaticity Index (SRBAI) Healthy Habits Subscale" is a self-report measure to assess how automatic or habitual certain behaviors are, often used to understand healthy habits. Healthy habits included are portion control, food tracking, protein content, eating vegetables, weighing self, physical activity, positive self-talk after a setback, arranging kitchen so he
Portion
Group
Value
95% CI
Single Arm
1.72
± 1.68
Tracking
Group
Value
95% CI
Single Arm
0.55
± 1.86
Points
Group
Value
95% CI
Single Arm
1.24
± 1.82
Vegetables
Group
Value
95% CI
Single Arm
0.48
± 1.4
Weighing
Group
Value
95% CI
Single Arm
1.29
± 2.01
Physically
Group
Value
95% CI
Single Arm
1.02
± 1.57
Self-Talk
Group
Value
95% CI
Single Arm
0.82
± 1.74
Healthy Food
Group
Value
95% CI
Single Arm
0.97
± 1.79
Changes in Weight Bias Internalization Scores From Week 0 to Week 24Secondary· 0 to 24 weeks
Effect of WW + WW Clinic (formerly known as Sequence) on absolute change of Weight Bias Internalization scores using "Weight Bias Internalization Scale" Scale Name + Description of scale: "Weight Bias Internalization Scale, WBIS-2F" is a 13-item measure developed to assess weight related self-stigma.
Scale Ranges (min, max): 13-91 Description of scoring: Lower scores indicate more weight related self-stigma, higher scores indicate less weight related self-stigma. A negative mean change indicates a decrease in weight related self-stigma.
Group
Value
95% CI
Single Arm
-7.12
± 9.83
Sponsor's own description
The study objective is to evaluate the efficacy of the WeightWatchers (WW) GLP-1 behavioral program + WW Clinic (formerly known as Sequence medical weight management program) on weight loss and related outcomes. Participants will be invited to take part and answer surveys at 0, 12 and 24 weeks.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
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· recruiting
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NCT07213466 — Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder
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NCT07165431 — Effect of a Postbiotic Supplementation in Overweight and Obese Subjects: A Randomized Controlled Trial (PARABIOTICS-2).
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
Last refreshed: 19 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06034457.