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NCT06024889
Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure.
Phase 1, PHASE2 trial testing Furosemide Injection in Acute Heart Failure in 20 participants. Completed in 9 February 2024.
9 February 2024
Quick facts
| Lead sponsor | Johannes Grand |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 1 September 2023 |
| Primary completion | 9 February 2024 |
| Estimated completion | 9 February 2024 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Furosemide Injection — full drug profile →
Conditions studied
- Acute Heart Failure — all drugs for Acute Heart Failure →
Sponsor
Johannes Grand — full company profile →
Who can join
18 and older, any sex, with Acute Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Intravenous (IV) loop diuretics have been a key component in treating pulmonary edema since the 1960s and has a Class 1 recommendation in the 2021 guidelines for acute heart failure. However, no randomized clinical trials have investigated loop diuretics versus other interventions for acute heart failure, and clinical knowledge of the hemodynamic effects of furosemide is based in studies from the 1970s. In this study, we aim to assess the acute effect of furosemide on cardiac filling pressures and pulmonary congestion. Hypothesis: Administration of furosemide induces a hyperacute (within 30 minutes) lowering of cardiac filling pressures and pulmonary congestion before significant diuresis occurs. Design: A prospective, interventional study including 20 patients admitted due to a clinical diagnosis of acute heart failure with pulmonary congestion. Intervention: 80 mg of furosemide is administered IV. Measurements include blood pressure, peripheral oxygen saturation, pulmonary fluid content by ReDS\*, ultrasound examination of heart and lungs, and assessment of cardiac filling pressures with doppler and strain analysis. Measurements are repeated at several time points until 6 hours have passed.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Acute haemodynamic and diuretic effects of intravenous furosemide in acute heart failure.
El Caidi NO, Lukoschewitz JD, Taraldsen IA, Hove J, et al · · 2026 · PMID 41773006 · DOI 10.61409/a07250556 -
The acute effects of furosemide in acute heart failure assessed by remote dielectric sensing. A protocol.
El Caidi NO, Lukoschewitz JD, Nielsen OW, Hove J, et al · · 2024 · PMID 38903022 · DOI 10.61409/a11230697
Verify or expand the search:
- PubMed search for NCT06024889
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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- medRxiv preprints
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Related trials
Other trials of Furosemide Injection
Trials testing the same drug.
- NCT06326112 — Role of Active Deresuscitation After Resuscitation: · Phase 2 · unknown
- NCT06273397 — Acetazolamide or Metolazone in Acute Heart Failure · NA · not yet recruiting
- NCT06229990 — A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy · Phase 4 · recruiting
- NCT05276219 — Optimized Treatment of Pulmonary Edema or Congestion · Phase 4 · recruiting
- NCT05939245 — Comparison of Plasma Neutrophil Gelatinase-Associated Lipocalin (pNGAL) Level in De-resuscitation With Furosemide Group · NA · completed
Other recruiting trials for Acute Heart Failure
Currently open trials in the same condition.
- NCT06587854 — a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure · recruiting
- NCT07008365 — The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure · Phase 3 · recruiting
- NCT06465498 — Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography · NA · recruiting
- NCT06597331 — Cardiac Assessment and Takotsubo-stunning Among COPD-exacerbations In-Hospital · recruiting
- NCT06166654 — Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload · Phase 4 · recruiting
Other Johannes Grand trials
Trials by the same sponsor.
- NCT06563609 — Combined Rehabilitation and Nutritional Support vs. Standard Care in In-Hospital Endocarditis Treatment · NA · terminated
- NCT06166654 — Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload · Phase 4 · recruiting
- NCT05276219 — Optimized Treatment of Pulmonary Edema or Congestion · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06024889 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johannes Grand
- Last refreshed: 16 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06024889.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing