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NCT06023901
The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis
NA trial testing Apical periodontitis in Periapical Periodontitis in 185 participants. Completed in 2 August 2023.
2 January 2022
Quick facts
| Lead sponsor | Istanbul Medipol University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 185 |
| Start date | 7 January 2021 |
| Primary completion | 2 January 2022 |
| Estimated completion | 2 August 2023 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Apical periodontitis
Conditions studied
- Periapical Periodontitis — all drugs for Periapical Periodontitis →
Sponsor
Istanbul Medipol University Hospital
Who can join
Adults 18 to 65, any sex, with Periapical Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A total of 185 subjects were divided into three categories: AP group (n=85), CP group (n=50) and healthy control group (n=50). The AP group was divided into 3 subgroups according to abscess scoring (AS-PAI) based on the periapical index. The CP group was divided into 4 subgroups according to the periodontitis staging system (PSS). After recording the demographic and clinical characteristics of all participants, blood and gingival crevicular fluid (GCF) samples were taken. TNF-α, IL-10, PGE2 and NO levels were measured in these samples.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The importance of mechanosensitive cell mediated prostaglandin and nitric oxide synthesis in the pathogenesis of apical periodontitis: comparative with chronic periodontitis.
Ozcelik F, Ersahan S, Sirin DA, Ozçelik IK, et al · · 2024 · cited 4× · PMID 38795217 · DOI 10.1007/s00784-024-05721-3
Verify or expand the search:
- PubMed search for NCT06023901
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06023901 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istanbul Medipol University Hospital
- Last refreshed: 27 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06023901.
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