NCT06023407 (FIGHT-AD) is a NA clinical trial of Water Immersion Heat Therapy in Healthy Aging, sponsored by University of Kansas Medical Center.

Who is sponsoring NCT06023407?

NCT06023407 is sponsored by University of Kansas Medical Center.

What drugs are being tested in NCT06023407?

Interventions in NCT06023407: Water Immersion Heat Therapy.

What condition does NCT06023407 study?

NCT06023407 studies Healthy Aging, Alzheimer Disease, Metabolic Disease.

Is NCT06023407 still recruiting?

NCT06023407 is currently enrolling by invitation. Last updated 17 April 2026.

Last reviewed 2026-04-17 · How we verify

NCT06023407: FIGHT-AD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Feasibility of Improving Glycemia With Heat Therapy to Prevent AD

ENROLLING BY INVITATION NA Last updated 17 April 2026

What this trial tests

NA trial testing Water Immersion Heat Therapy in Healthy Aging in 60 participants. Enrolling by invitation.

Timeline

27 February 2024

Primary endpoint
29 October 2027

31 March 2028

Quick facts

Lead sponsor	University of Kansas Medical Center
Phase	NA
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	60
Start date	27 February 2024
Primary completion	29 October 2027
Estimated completion	31 March 2028
Sites	1 location across United States

Drugs / interventions tested

Water Immersion Heat Therapy

Conditions studied

Healthy Aging — all drugs for Healthy Aging →
Alzheimer Disease — all drugs for Alzheimer Disease →
Metabolic Disease — all drugs for Metabolic Disease →

Sponsor

University of Kansas Medical Center

Who can join

65 and older, any sex, with Healthy Aging or Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators will determine if heat therapy can improve blood (Aim 1) and brain (Aim 2) glucose metabolism in cognitively healthy older adults (65+) who are at risk for AD. The investigators will also examine the degree to which changes in blood and brain glucose metabolism track together and explore several additional potential mechanisms that are critical to understanding the brain benefits of heat therapy (Aim 3). These aims will provide a comprehensive understanding of the impact of heat therapy on whole body metabolic function and brain health.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Improving glycemic control via heat therapy in older adults at risk for Alzheimer's disease (FIGHT-AD): a pilot study.
Blankenship AE, Kemna R, Kueck PJ, John C, et al · · 2025 · cited 6× · PMID 39829076 · DOI 10.1152/japplphysiol.00396.2024
Heat therapy in individuals at risk for Alzheimer's disease-methods for a randomized controlled trial.
Geiger PC, Pennington JS, Kueck PJ, John CS, et al · · 2026 · PMID 41657418 · DOI 10.3389/fneur.2026.1736108

Verify or expand the search:

Other recruiting trials for Healthy Aging

Currently open trials in the same condition.

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NCT07151365 — Plant-based Diets and Healthy Aging · recruiting

Other University of Kansas Medical Center trials

Trials by the same sponsor.

NCT06636214 — Adapting Changing Talk: Online (CHATO) to CHATO-Inclusive · NA · not yet recruiting
NCT07528963 — KanSurvive 2.0: Testing Enhanced Models of Cancer Survivorship Care for Rural Cancer Survivors in Primary Care Practice · NA · enrolling by invitation
NCT07463755 — Low-Fidelity Driving Simulator Training in Parkinson's Disease. · NA · not yet recruiting
NCT07420621 — Preliminary Effectiveness of Enhanced Text Message + Incentives · NA · recruiting
NCT07491510 — Improving Prenatal Care to Reduce Early Onset Preeclampsia in Low-Income · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06023407 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Kansas Medical Center
Last refreshed: 17 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06023407.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing