NCT06018545 (AI-REACT) is a clinical trial of Ground truthing in Intracranial Hemorrhages, sponsored by Oxford University Hospitals NHS Trust.

Who is sponsoring NCT06018545?

NCT06018545 is sponsored by Oxford University Hospitals NHS Trust.

What drugs are being tested in NCT06018545?

Interventions in NCT06018545: Ground truthing, Reading.

What condition does NCT06018545 study?

NCT06018545 studies Intracranial Hemorrhages, Acute Ischemic Stroke, Hydrocephalus, Cerebral Infarction, Cerebral Edema, Cerebral Injury.

Is NCT06018545 still recruiting?

NCT06018545 is currently completed. Last updated 24 November 2025.

Last reviewed 2025-11-24 · How we verify

NCT06018545: AI-REACT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation

Completed Last updated 24 November 2025

What this trial tests

trial testing Ground truthing in Intracranial Hemorrhages in 33 participants. Completed in 1 June 2025.

Timeline

1 June 2023

Primary endpoint
1 September 2023

1 June 2025

Quick facts

Lead sponsor	Oxford University Hospitals NHS Trust
Status	Completed
Study type	OBSERVATIONAL
Enrollment	33
Start date	1 June 2023
Primary completion	1 September 2023
Estimated completion	1 June 2025
Sites	4 locations across United Kingdom

Drugs / interventions tested

Ground truthing
Reading

Conditions studied

Intracranial Hemorrhages — all drugs for Intracranial Hemorrhages →
Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →
Hydrocephalus — all drugs for Hydrocephalus →
Cerebral Infarction — all drugs for Cerebral Infarction →

Sponsor

Oxford University Hospitals NHS Trust

Who can join

Eligibility, any sex, with Intracranial Hemorrhages or Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838). The purpose of the study is to assess the impact of an Artificial Intelligence (AI) tool called qER 2.0 EU on the performance of readers, including general radiologists, emergency medicine clinicians, and radiographers, in interpreting non-contrast CT head scans. The study aims to evaluate the changes in accuracy, review time, and diagnostic confidence when using the AI tool. It also seeks to provide evidence on the diagnostic performance of the AI tool and its potential to improve efficiency and patient care in the context of the National Health Service (NHS). The study will use a dataset of 150 CT head scans, including both control cases and abnormal cases with specific abnormalities. The results of this study will inform larger follow-up studies in real-life Emergency Department (ED) settings.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

AI assisted reader evaluation in acute CT head interpretation (AI-REACT): protocol for a multireader multicase study.
Fu H, Novak A, Robert D, Kumar S, et al · · 2024 · cited 4× · PMID 38346874 · DOI 10.1136/bmjopen-2023-079824
Artificial Intelligence-assisted reader evaluation in acute CT head interpretation (AI-REACT): a multireader multicase study
Novak A, Shah R, Espinosa Morgado AT, Robert D, et al · · 2025 · DOI 10.1101/2025.10.17.25337471

Verify or expand the search:

Other trials of Ground truthing

Trials testing the same drug.

NCT06130397 — AI Assisted Detection of Fractures on X-Rays (FRACT-AI) · completed
NCT06075836 — AI Assisted Detection of Chest X-Rays · completed

Other recruiting trials for Intracranial Hemorrhages

Currently open trials in the same condition.

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NCT06404645 — A Clinical Prospective Observational Study of Near Infrared Spectroscopy to Detect Subcranial Hematoma · recruiting

Other Oxford University Hospitals NHS Trust trials

Trials by the same sponsor.

NCT07303582 — Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities · Phase 4 · recruiting
NCT06922695 — Responding to AF: Pill-in-Pocket Anticoagulation Guided by Automated Monitoring and Alerts · NA · recruiting
NCT06822686 — Autologous Stem Cells in the Management of Fistulating Perianal Crohn's Disease · NA · not yet recruiting
NCT06397664 — The Impact of Chronic Adolescent Skin Conditions on Sexual Health · completed
NCT06130397 — AI Assisted Detection of Fractures on X-Rays (FRACT-AI) · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06018545 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Oxford University Hospitals NHS Trust
Last refreshed: 24 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06018545.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing