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NCT06007560: HMOVE
Aerobe Cycling Training in Women With Unexplained Recurrent Pregnancy Loss
NA trial testing Exercise in Recurrent Pregnancy Loss in 30 participants. Participants enrolled and being followed up; not accepting new ones.
1 December 2024
Quick facts
| Lead sponsor | Radboud University Medical Center |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 21 March 2022 |
| Primary completion | 1 December 2024 |
| Estimated completion | 1 June 2026 |
| Sites | 2 locations across Netherlands |
Drugs / interventions tested
- Exercise
Conditions studied
- Recurrent Pregnancy Loss — all drugs for Recurrent Pregnancy Loss →
Sponsor
Radboud University Medical Center
Who can join
Under 40, female only, with Recurrent Pregnancy Loss. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In 50% of women with recurrent pregnancy loss (RPL) miscarriages are unexplained, therefore no therapeutic intervention is possible. In a pilot study, women with unexplained RPL showed less endometrial NK cells (eNK) compared to women with a previously uncomplicated pregnancy. It is known that eNK cells are important for embryo implantation during early pregnancy. Investigators presume that high sympathetic activity in these women is related to eNK cell number, function and phenotype and that exercise is an effective intervention to lower sympathetic activity and to influence the immune system, as especially peripheral NK cells have been assumed to be responsive to physical training. The investigators hypothesize that moderate exercise can lower the adrenergic tone of the sympathetic nervous system hereby influencing endometrial NK cells in women with RPL and eventually pregnancy outcome.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure.
Guan D, Chen Z, Zhang Y, Sun W, et al · · 2025 · cited 7× · PMID 40325291 · DOI 10.1111/cpr.70037
Verify or expand the search:
- PubMed search for NCT06007560
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Recurrent Pregnancy Loss
Currently open trials in the same condition.
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- NCT05989178 — Prospective Recurrent Pregnancy Loss Registry · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06007560 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
- Last refreshed: 6 April 2025
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