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NCT06005558
Low Dose Versus High Dose Methylene Blue in Septic Patients
Phase 2, PHASE3 trial testing Normal saline in Septic Shock in 90 participants. Completed in 15 May 2024.
29 April 2024
Quick facts
| Lead sponsor | National Cancer Institute, Egypt |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 90 |
| Start date | 1 August 2023 |
| Primary completion | 29 April 2024 |
| Estimated completion | 15 May 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Normal saline
- Methylene Blue low dose — full drug profile →
- Methylene Blue high dose — full drug profile →
Conditions studied
- Septic Shock — all drugs for Septic Shock →
Sponsor
National Cancer Institute, Egypt
Who can join
Adults 18 to 65, any sex, with Septic Shock. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The main aim of this study is to examine the various effects of continuous methylene blue infusion in septic cancer patients and to compare it with the traditional infusion of noradrenaline in such patients .
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparative study between high and low dose methylene blue infusion in septic cancer patients: a randomized, blinded, controlled study.
Shaker EH, Soliman AM, Bedewy AAE, Elrawas MM. · · 2025 · cited 6× · PMID 39780053 · DOI 10.1186/s12871-024-02792-3
Verify or expand the search:
- PubMed search for NCT06005558
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Septic Shock
Currently open trials in the same condition.
- NCT07179276 — Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock · NA · recruiting
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- NCT07419802 — OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study · recruiting
- NCT07264543 — Early Methylene Blue in the Microhemodynamics of Septic Patients · Phase 2, PHASE3 · recruiting
- NCT04855786 — External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients · NA · recruiting
Other National Cancer Institute, Egypt trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06005558 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Cancer Institute, Egypt
- Last refreshed: 5 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06005558.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing