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NCT06000930: MaraCat2
Cardiac Troponin Fragmentation After Heavy Physical Exercise The MaraCat2 Study
trial testing Troponin fragmentation in Myocardial Infarction in 170 participants. Enrolling by invitation.
1 September 2024
Quick facts
| Lead sponsor | University of Turku |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 170 |
| Start date | 19 August 2023 |
| Primary completion | 1 September 2024 |
| Estimated completion | 1 September 2024 |
| Sites | 1 location across Finland |
Drugs / interventions tested
- Troponin fragmentation
Conditions studied
- Myocardial Infarction — all drugs for Myocardial Infarction →
- Myocardial Injury — all drugs for Myocardial Injury →
Sponsor
University of Turku
Who can join
Adults 18 to 80, any sex, with Myocardial Infarction or Myocardial Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cardiac troponins are highly sensitive and specific biomarkers of cardiac injury and are in a key role in the diagnosis of acute myocardial infarction (MI). Minor troponin elevations are common after prolonged strenuous exercise without clinical symptoms of MI or myocardial injury. Importantly, currently used high-sensitivity troponin T (cTnT) test detects also smaller troponin fragments which may cause troponin elevation after exercise and lead to false diagnosis of MI. In the present study protocol, we compare the characteristics troponin release after marathon race and Type 1 MI with the improved version of our novel troponin fragmentation test (SuperTropo test) and the commercial cTnT test. A total of 65 recreational runners participating in the 2023 Paavo Nurmi Marathon in Turku are recruited. All participants give a blood sample during the post-race visit (within 30 min after finishing the marathon). A control group of 90 patients with acute Type 1 MI are recruited among patients admitted to Heart Centre of Turku University Hospital. Commercial cTnT and long troponin component of cTnT analyzed witha novel immunoassay are dtermined in all subjects to assess cTnT fragmentation. TYhe main aims of the study are: To assess how often cTnT is elevated after marathon running and which factors affect the cTnT rise? Is the fragmentation of troponin more common after marathon race compared with Type 1 MI and can the novel Supertropo test separate execise-induced troponin rise from those caused by MI ?
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Composition of cardiac troponin release differs after marathon running and myocardial infarction.
Airaksinen KEJ, Paana T, Vasankari T, Salonen S, et al · · 2024 · cited 11× · PMID 39551608 · DOI 10.1136/openhrt-2024-002954 -
Cardiac Troponin Fragmentation After Heavy Physical Exercise The MaraCat2 Study
Airaksinen KEJ, Paana T, Hellman T, Vasankari T, et al · · 2024 · DOI 10.1101/2024.05.07.24307024
Verify or expand the search:
- PubMed search for NCT06000930
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06000930 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Turku
- Last refreshed: 8 May 2024
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