Last reviewed · How we verify
NCT06000592
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
NA trial testing Digitimer in Acute Spinal Cord Injury in 50 participants. Currently enrolling.
31 August 2026
Quick facts
| Lead sponsor | Jill M. Wecht, Ed.D. |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 1 January 2022 |
| Primary completion | 31 August 2026 |
| Estimated completion | 1 October 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Digitimer
Conditions studied
- Acute Spinal Cord Injury — all drugs for Acute Spinal Cord Injury →
- Spinal Cord Injuries — all drugs for Spinal Cord Injuries →
- Neuromodulation — all drugs for Neuromodulation →
- Traumatic Spinal Cord Injury — all drugs for Traumatic Spinal Cord Injury →
Sponsor
Jill M. Wecht, Ed.D.
Who can join
Adults 14 to 100, any sex, with Acute Spinal Cord Injury or Spinal Cord Injuries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Current forms of pharmacologic and non-pharmacologic treatments for hypotension and orthostatic hypotension (OH) remain inadequate during acute inpatient rehabilitation (AIR) following a traumatic spinal cord injury (SCI). A critical need exists for the identification of safe, practical, and effective treatment options that stabilize blood pressure (BP) after traumatic SCI. Recent published evidence suggests that transcutaneous Spinal Cord Stimulation (TSCS) can be used to raise seated BP, and mitigate the falls in BP during orthostatic repositioning in individuals with chronic SCI. This site-specific project will focus on the use of TSCS to stabilizing seated BP and mitigate the fall in BP during orthostatic repositioning during AIR following traumatic SCI.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Autonomic dysfunction and hemodynamic management after acute spinal cord injury: blood pressure targets, perfusion strategies, and emerging therapies.
Johnston DT, Grau JW. · · 2025 · PMID 41567537 · DOI 10.3389/fneur.2025.1716013
Verify or expand the search:
- PubMed search for NCT06000592
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Spinal Cord Injury
Currently open trials in the same condition.
- NCT06452264 — Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study · NA · recruiting
- NCT06238492 — A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI · NA · recruiting
- NCT06654804 — Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury · Phase 4 · recruiting
- NCT05745298 — The Use of Functional Electrical Stimulation in Conjunction With Respiratory Muscle Training to Improve Unaided Cough in · NA · recruiting
- NCT05244408 — "SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06000592 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jill M. Wecht, Ed.D.
- Last refreshed: 2 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06000592.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing