NCT05993715

Nitrate Supplementation on Motor Unit Activity

Completed NA Last updated 15 August 2023

What this trial tests

NA trial testing Nitrate supplementation in Dietary Supplements in 14 participants. Completed in 1 March 2020.

Timeline

4 December 2019

Primary endpoint
3 February 2020

1 March 2020

Quick facts

Lead sponsor	Northumbria University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	other
Enrollment	14
Start date	4 December 2019
Primary completion	3 February 2020
Estimated completion	1 March 2020
Sites	1 location across United Kingdom

Drugs / interventions tested

• Nitrate supplementation
• Placebo supplementtaion

Conditions studied

• Dietary Supplements — all drugs for Dietary Supplements →
• Healthy — all drugs for Healthy →

Sponsor

Northumbria University

Who can join

Adults 18 to 30, male only, with Dietary Supplements or Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aimed to assess if nitrate supplementation influence motor unit (MU) activity following a sustained ischemic contraction and whether this is affected by blood flow restriction (BFR) during the recovery period. Fourteen male participants (mean ± SD, 25 ± 6 years) completed two experimental trials following 5-days of supplementation with either nitrate-rich (NIT) or nitrate-depleted (PLA) beetroot juice in a randomized, double-blinded, cross-over design. Intramuscular electromyography was used to assess MU potential (MUP) size and firing rates (MUFR) during a submaximal (25% MVC) sustained isometric contraction with BFR. These variables were also assessed during a 90 s recovery period with the first half completed with, and the second half completed without, BFR. Nitrate supplementation can expedite the recovery of MUP duration following a sustained ischemic contraction in healthy adults. These novel observations improve understanding of the effects of nitrate on the recovery of neuromuscular function post-exercise and might have implications for recovery of muscle contractile function.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Influence of nitrate supplementation on motor unit activity during recovery following a sustained ischemic contraction in recreationally active young males.
   Esen O, Bailey SJ, Stashuk DW, Howatson G, et al · · 2024 · cited 3× · PMID 38809323 · DOI 10.1007/s00394-024-03440-9