Last reviewed · How we verify
NCT05990101: Hyper-AP
HYPoxaEmic Respiratory Failure and Awake Prone Ventilation
NA trial testing Awake prone position (APP) in Respiratory Failure in 262 participants. Currently enrolling.
1 August 2026
Quick facts
| Lead sponsor | Vilnius University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 262 |
| Start date | 12 May 2023 |
| Primary completion | 1 August 2026 |
| Estimated completion | 1 September 2028 |
| Sites | 4 locations across United Kingdom, Lithuania |
Drugs / interventions tested
- Awake prone position (APP)
Conditions studied
- Respiratory Failure — all drugs for Respiratory Failure →
- Hypoxemia — all drugs for Hypoxemia →
Sponsor
Vilnius University
Who can join
18 and older, any sex, with Respiratory Failure or Hypoxemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this prospective multi-centre randomised controlled trial is to determine if addition of awake prone positioning to standard oxygen, high flow oxygen therapy and non-invasive ventilation may reduce the rates of endotracheal intubation and mechanical ventilation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05990101
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Vilnius University trials
Trials by the same sponsor.
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- NCT06651411 — The Feasibility of Chatbot-based Stress Management Intervention STARS for Youth in Lithuania · NA · active not recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05990101 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vilnius University
- Last refreshed: 14 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05990101.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing