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NCT05985733
Evaluation of Oxidative Stress and Inflammation Markers in Temporomandibular Disorders
trial testing Biochemical analysis in Temporomandibular Disorder in 44 participants. Completed in 19 April 2023.
28 March 2023
Quick facts
| Lead sponsor | Bahçeşehir University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 44 |
| Start date | 19 June 2020 |
| Primary completion | 28 March 2023 |
| Estimated completion | 19 April 2023 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Biochemical analysis
Conditions studied
- Temporomandibular Disorder — all drugs for Temporomandibular Disorder →
- Oxidative Stress — all drugs for Oxidative Stress →
- Inflammation — all drugs for Inflammation →
Sponsor
Bahçeşehir University
Who can join
Adults 14 to 40, any sex, with Temporomandibular Disorder or Oxidative Stress. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: The occurrence of many diseases has been associated with oxidative stress and disruption of antioxidant mechanisms. Temporomandibular Joint(TMJ) Disorders are also thought to develop with the onset of the destructive process in the tissues as a result of this balance being disrupted. Purpose: This study was designed to compare salivary and serum oxidative stress and inflammation markers of individuals with Temporomandibular Disorders (TMD) and healthy subjects. Study design, setting, and sample: A prospective cross-sectional study was conducted. 27 TMD patients diagnosed with disc displacement (DD) according to RDC/TMD and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum and saliva samples were taken from the patients and centrifuged, and stored at -80°C until analyzed. All samples were examined for IL-6, MDA and 8-OHdG concentrations. Predictor variable: Diagnosis of disc displacement (RDC/TMD) Main outcome variables: Levels of 8-OHdG, IL-6 and MDA Covariates: Age and gender
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05985733
- Europe PMC full search
- ASCO Meeting Library
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Other recruiting trials for Temporomandibular Disorder
Currently open trials in the same condition.
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Other Bahçeşehir University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05985733 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bahçeşehir University
- Last refreshed: 14 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05985733.
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