Last reviewed · How we verify
NCT05975541: SIDERALE
Susceptibility to Infectious Diseases in Obesity
trial testing Observational in Obesity in 80 participants. Status unknown.
25 February 2025
Quick facts
| Lead sponsor | Azienda Ospedaliero Universitaria Maggiore della Carita |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 80 |
| Start date | 1 October 2023 |
| Primary completion | 25 February 2025 |
| Estimated completion | 1 October 2025 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Observational — full drug profile →
Conditions studied
- Obesity — all drugs for Obesity →
- Type2diabetes — all drugs for Type2diabetes →
- Gut Microbiota — all drugs for Gut Microbiota →
- Chronic Disease — all drugs for Chronic Disease →
Sponsor
Azienda Ospedaliero Universitaria Maggiore della Carita — full company profile →
Who can join
Adults 18 to 65, any sex, with Obesity or Type2diabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and infectious disorders as represented by the emerging discipline "therapeutic microbiology". The gut microbiota is strictly interconnected with obesity and T2D playing also an important role in immune system regulation. Obesity and diabetes can lead to chronic inflammation, which results in the secretion of pro-inflammatory cytokines like IL-6, IL-1, and TNF-alpha, causing immune system alteration which predisposes patients with obesity and T2D to chronic infections. Therefore, the principal aim of the study is to investigate changes in gut microbiota composition between patients with chronic infections or not, so as to attribute to specific phyla the formation of the infections in these patients.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05975541
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05975541 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Ospedaliero Universitaria Maggiore della Carita
- Last refreshed: 30 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05975541.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing