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NCT05975190: B-REST
Respiratory Training and Relaxation Techniques to Improve Adjuvant Radiation Therapy in DIBH in Breast Cancer
NA trial testing Respiratory training and relaxation techniques under adjuvant radiation therapy in DIBH in breast cancer in Radiotherapy in 108 participants. Status unknown.
1 July 2025
Quick facts
| Lead sponsor | Technical University of Munich |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 108 |
| Start date | 22 June 2022 |
| Primary completion | 1 July 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Respiratory training and relaxation techniques under adjuvant radiation therapy in DIBH in breast cancer
Conditions studied
- Radiotherapy — all drugs for Radiotherapy →
- Breast Cancer — all drugs for Breast Cancer →
- Relaxation — all drugs for Relaxation →
- Breathholding — all drugs for Breathholding →
Sponsor
Technical University of Munich
Who can join
18 and older, female only, with Radiotherapy or Breast Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this prospective clinical trial is to improve patient compliance and performance of deep inspiration breath hold (DIBH) to further reduce the cardiac dose from left breast radiation, and to improve cooperation and patient satisfaction through an active and formal pre-treatment respiratory training program combined with relaxation training (R\&R) in breast cancer patients undergoing adjuvant radiotherapy for left sided breast cancer. The main questions the study aims to answer are: * Does the use of communication training and the use of relaxation techniques (R\&R) reduce the Maximum dose to the heart (Dmax) and improve further heart dose parameters in deep inspiration during adjuvant radiotherapy for breast cancer? * Does R\&R improve longitudinal anxiety and quality of life under patients undergoing DIBH adjuvant radiotherapy for left sided breast cancer? Participants will be randomly assigned to either an experimental arm, which will receive the R\&R, versus a standard arm that will not receive the R\&R. * training program in the experimental arm includes breath hold training, music, and nature sounds that patients can listen to on an MP3 player * both groups complete standardized questionnaires about their well-being and satisfaction at prospective time points before, during the radiation treatment course, as well as at 6 weeks follow-up Researchers will compare the R\&R group (interventional arm) to current conventional DIBH instruction (standard group) to see if Dmax to the heart decreases and compliance and satisfaction under patients rises.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Assessment of the impact of age on DIBH in radiotherapy based on the prospective GATTUM and B-REST trials.
Moser R, Buchecker LM, Bohlen JM, Düsberg M, et al · · 2025 · PMID 40612359 · DOI 10.1016/j.ctro.2025.100956
Verify or expand the search:
- PubMed search for NCT05975190
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05975190 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Technical University of Munich
- Last refreshed: 3 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05975190.
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