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NCT05974995: RObese
Robotic-assisted Versus Conventional Laparoscopic Surgery in Obese Patients With Early Endometrial Cancer
NA trial testing Robot-assisted surgery in Endometrial Cancer in 566 participants. Currently enrolling.
1 September 2026
Quick facts
| Lead sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 566 |
| Start date | 1 September 2023 |
| Primary completion | 1 September 2026 |
| Estimated completion | 1 September 2029 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Robot-assisted surgery
- Laparoscopic surgery
Conditions studied
- Endometrial Cancer — all drugs for Endometrial Cancer →
- Endometrial Neoplasms — all drugs for Endometrial Neoplasms →
- Obesity, Morbid — all drugs for Obesity, Morbid →
- Gynecologic Cancer — all drugs for Gynecologic Cancer →
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Who can join
Adults 18 to 75, female only, with Endometrial Cancer or Endometrial Neoplasms. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Data across literature suggest that robotic surgery may offer benefit specifically in patient with morbid obesity with endometrial cancer, but to date no randomized trials have been conducted to confirm these observations. This randomized controlled multicentric trial aims to evaluate the most appropriate minimally invasive surgical approach in morbidly obese (BMI \>= 30) patients with endometrial carcinoma.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Robotic-assisted versus conventional laparoscopic surgery in the management of obese patients with early endometrial cancer in the sentinel lymph node era: a randomized controlled study (RObese).
Dinoi G, Tarantino V, Bizzarri N, Perrone E, et al · · 2024 · cited 14× · PMID 38326228 · DOI 10.1136/ijgc-2023-005197 -
Robotic platforms in gynaecological surgery: past, present, and future.
Pavone M, Baroni A, Taliento C, Goglia M, et al · · 2024 · cited 10× · PMID 38950530 · DOI 10.52054/fvvo.16.2.024 -
Surgery Advances in Gynecologic Tumors: The Evolution and Outcomes of Robotic Surgery for Gynecologic Cancers in a Tertiary Center.
Knigin D, Brezinov Y, Salvador S, Lau S, et al · · 2024 · cited 1× · PMID 38785460 · DOI 10.3390/curroncol31050179 -
Robotic Surgical Outcomes in Endometrial Cancer: Does Class III Obesity Matter?
Capozzi V, Gallinelli A, Scarpelli E, Restaino S, et al · · 2026
Verify or expand the search:
- PubMed search for NCT05974995
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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- NCT06856356 — Clinical Efficacy and Safety of Robot-assisted Total Knee Arthroplasty · NA · recruiting
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Other recruiting trials for Endometrial Cancer
Currently open trials in the same condition.
- NCT07419841 — A Phase 1 Study of the Safety and Tolerability of CTX-10726 · Phase 1 · recruiting
- NCT07382583 — Development of a Shared Decision Tool to Facilitate Uptake of the Levonorgestrel-releasing Intrauterine System for the P · recruiting
- NCT07377734 — Intrauterine Injection of Type III Collage in FST of EC/AEH · Phase 2 · recruiting
- NCT07319429 — Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification · Phase 2, PHASE3 · recruiting
- NCT07397624 — Endoscopic Suture Gastroplasty (ESG) for Treatment of Obese Patients With Endometrial Cancer · recruiting
Other Fondazione Policlinico Universitario Agostino Gemelli IRCCS trials
Trials by the same sponsor.
- NCT07514572 — Impact of Estimated Weight and Height on Nutritional Assessment in Elderly · NA · not yet recruiting
- NCT07504679 — Adipose Visceral and Epicardial Risk Evaluation · NA · not yet recruiting
- NCT07520643 — MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling · not yet recruiting
- NCT07479238 — Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy · not yet recruiting
- NCT07494227 — Development of the SC-IBD Self-Care Measurement Scale · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05974995 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Last refreshed: 3 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05974995.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing