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NCT05972798
Exploration of the Potential Mechanisms of n-3 Fatty Acids Supplementation in Depression and Cognitive Function in Patients With Late-life Depression
NA trial testing Omega-3 fatty acids in Late Life Depression in 30 participants. Completed in 25 December 2020.
25 September 2018
Quick facts
| Lead sponsor | Chang Gung Memorial Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 25 September 2018 |
| Primary completion | 25 September 2018 |
| Estimated completion | 25 December 2020 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Omega-3 fatty acids — full drug profile →
- Soybean oil — full drug profile →
Conditions studied
- Late Life Depression — all drugs for Late Life Depression →
Sponsor
Chang Gung Memorial Hospital
Who can join
60 and older, any sex, with Late Life Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Depression in the elderly causes considerable distress, disability, and loss of life. The accelerating aging boom is accentuating the importance of addressing late life depression (LLD). Extensive efforts in searching for effective and safety treatment yielded unsatisfactory results. Among the multiple agents in LLD treatment, long-chain polyunsaturated omega-3 fatty acids (omega-3 PUFA) stands out as an interesting compound as it addressed two main features in LLD, depressive mood and cognitive function. However, how it affects the brain remains unknown. Therefore, in an on-going double-blind randomized placebo-controlled study using 48 weeks omega-3 PUFA supplement in LLD treatment, we plan to perform two MRI scans (pre-treatment and post-treatment), in an effort to understand the unique neurobiology of omega-3 PUFA in the treatment of LLD. Along the trial, neuropsychological function and associated inflammatory markers were also collected.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05972798
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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Related trials
Other trials of Omega-3 fatty acids
Trials testing the same drug.
- NCT07363551 — Omega-3 Fatty Acids, Inflammation, Gut Microbiota in Youth With Depression · NA · recruiting
- NCT04485871 — Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids · NA · recruiting
- NCT03994055 — Effect of an Anti-inflammatory Diet on Patients With Cervical Cancer · NA · completed
- NCT03510715 — An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia · Phase 3 · completed
- NCT03603041 — Nutrition, Body Composition, and Sleep · NA · completed
Other recruiting trials for Late Life Depression
Currently open trials in the same condition.
- NCT06447428 — One-Year Trajectory of Cognitive Changes in Patients With Late-life Depression in the Short Term · recruiting
- NCT04469959 — Dopaminergic Dysfunction in Late-Life Depression · Phase 2 · active not recruiting
Other Chang Gung Memorial Hospital trials
Trials by the same sponsor.
- NCT07419789 — Precision Care for Older Persons · NA · not yet recruiting
- NCT07248345 — Virtual Reality Intervention for Family Caregivers of Persons Living With Dementia · NA · not yet recruiting
- NCT07036978 — Metabolomic and Immune-Microbiome Profiling for Unresectable Pancreatic Cancer · not yet recruiting
- NCT07489833 — Metabolomic Pathways and Traditional Chinese Medicine Body Constitution in Cancer-related Fatigue · not yet recruiting
- NCT07496528 — The ACURE Trial: Acupuncture for Colorectal Recovery · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05972798 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chang Gung Memorial Hospital
- Last refreshed: 2 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05972798.
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