Association of Long-term Use of Calcium Channel Blockers (CCB) and Risk of Breast Cancer: A Retrospective Longitudinal Observational Study

NCT05972785 ACTIVE_NOT_RECRUITING

The goal of this retrospective observational study is to examine whether long-term calcium channel blocker (CCB) use is associated with the development of breast cancer amongst women enrolled in three longitudinal cohort studies in Australia and the Netherlands . The main questions it aims to answer are: * Is long-term CCB use associated with the development of breast cancer amongst women enrolled in three longitudinal cohort studies in Australia and the Netherlands and what is the dose-response nature of this association. * Does differences in the association between calcium channel blocker use and the development of breast cancer exist between Australian and Dutch women. The investigators will utilise data from the Australian Longitudinal Study on Women's Health (ALSWH) , 45 and Up Study and Rotterdam study.

Details

Lead sponsor	Curtin University
Status	ACTIVE_NOT_RECRUITING
Enrolment	68500
Start date	2022-07-01
Completion	2025-12

Conditions

• Hypertension,Essential
• Breast Cancer

Interventions

• Calcium channel blocker
• Beta blocker
• Diuretic
• RAS
• Other AHT
• None AHT

Primary outcomes

• Incident rate of invasive breast cancer — From cohort entry until the earliest date of one of the following: a diagnosis of invasive breast cancer, bilateral mastectomy (without breast cancer) or death, assessed up to 14 years.
  The outcome will be defined based on the ICD-10 code of C50.x (malignant neoplasm of breast).

Countries

Australia