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NCT05971186
Dark Chocolate, Coconut Water, and Ibuprofen in Managing Primary Dysmenorrhea
Phase 2 trial testing Ibuprofen 400 mg in Dysmenorrhea Primary in 45 participants. Completed in 15 August 2022.
15 August 2022
Quick facts
| Lead sponsor | Universitas Padjadjaran |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 30 June 2022 |
| Primary completion | 15 August 2022 |
| Estimated completion | 15 August 2022 |
| Sites | 1 location across Indonesia |
Drugs / interventions tested
- Ibuprofen 400 mg — full drug profile →
- Young Coconut Water
- Dark Chocolate Bar
Conditions studied
- Dysmenorrhea Primary — all drugs for Dysmenorrhea Primary →
- Menstrual Pain — all drugs for Menstrual Pain →
- Ibuprofen — all drugs for Ibuprofen →
Sponsor
Universitas Padjadjaran — full company profile →
Who can join
Adults 17 to 24, female only, with Dysmenorrhea Primary or Menstrual Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Dysmenorrhea, the painful condition experienced by women during menstruation, affects a significant proportion of women worldwide and often leads to decreased productivity. Various pharmacological and non-pharmacological treatments are available for pain relief, but information on their effectiveness, particularly regarding green coconut water, dark chocolate, and Ibuprofen, remains limited. This study aimed to compare the effectiveness of green coconut water, dark chocolate bars, and Ibuprofen in reducing the intensity of primary dysmenorrhea. A randomized controlled trial with a quantitative design was conducted, involving 45 participants randomly assigned to receive either 330 ml of green coconut water, 35 grams of 70% dark chocolate, or 400 mg Ibuprofen. Pain intensity was measured before and after treatment.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Single-Blind Randomized Controlled Trial: Comparative Efficacy of Dark Chocolate, Coconut Water, and Ibuprofen in Managing Primary Dysmenorrhea.
Nuha K, Rusmil K, Ganiem AR, Permadi W, et al · · 2023 · cited 3× · PMID 37623203 · DOI 10.3390/ijerph20166619
Verify or expand the search:
- PubMed search for NCT05971186
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05971186 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitas Padjadjaran
- Last refreshed: 2 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05971186.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing