Last reviewed · How we verify
NCT05971095: NEPFAR
Comparison Between Percutaneous Femoral Nerve Neuromodulation Associated With Femoral Nerve Block and Standard Clinical Practice in Patients Undergoing Knee Arthroplasty.
NA trial testing Percutaneous neuromodulation using the EPTE® Bipolar System device in Acute Pain in 64 participants. Status unknown.
1 January 2024
Quick facts
| Lead sponsor | Hospital General Universitario de Valencia |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 64 |
| Start date | 1 June 2023 |
| Primary completion | 1 January 2024 |
| Estimated completion | 1 May 2024 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Percutaneous neuromodulation using the EPTE® Bipolar System device
Conditions studied
- Acute Pain — all drugs for Acute Pain →
Sponsor
Hospital General Universitario de Valencia
Who can join
18 and older, any sex, with Acute Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare the maximum isometric contraction force differential of the quadriceps in the postoperative period after the use of a peripheral nerve neuromodulation program in patients undergoing knee arthroplasty. The main questions it aims to answer are if the combination of a peripheral neuromodulation program in the perioperative period improves analgesic quality and short-term functional recovery in patients undergoing knee arthroplasty, Participants will be asked to reach a maximum knee extension prior to neurostimulation Patients will have the electrodes inserted under direct ultrasound vision and placed near the femoral nerve. Researchers will compare whether there is a difference in both quadriceps contraction force and analgesia between the stimulated group and the control group.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Systematic Review of Temporary Peripheral Nerve Stimulation for Postoperative Pain Management in Orthopedic Surgery.
Harris JC, Pierson CJ, Konda C, Jain NB. · · 2025 · PMID 41409093 · DOI 10.1155/anrp/8477771
Verify or expand the search:
- PubMed search for NCT05971095
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Pain
Currently open trials in the same condition.
- NCT06779604 — Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery · recruiting
- NCT07348419 — Quadro-Iliac vs Thoracolumbar Interfascial Plane Block for Analgesia After Single-Level Lumbar Disc Surgery · NA · recruiting
- NCT07335159 — Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention · NA · recruiting
- NCT07348523 — Comparison of the Postoperative Analgesic Efficacy of Classical and Modified Erector Spinae Plane Blocks After Lumbar Sp · NA · recruiting
- NCT07336264 — Characterization of Acute Pain · recruiting
Other Hospital General Universitario de Valencia trials
Trials by the same sponsor.
- NCT05873894 — Acute Pain Oscillation in Electroencephalographic Monitoring Under General Anaesthesia · recruiting
- NCT04755478 — LUS to Assess Lung Injury After Lung Lobectomy · unknown
- NCT04581096 — Mapping COVID-19 Spread in a Tertiary Hospital · completed
- NCT04506515 — Psychological Impact of COVID-19 Pandemic in Healthcare Workers · completed
- NCT03902704 — Safety and Efficacy of Cleverscope. A New Medical Device for Tracheal Intubation · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05971095 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital General Universitario de Valencia
- Last refreshed: 2 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05971095.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing