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NCT05969119
Addition of Pyridostigmine to Conventional Management of Postdural Puncture Headache
Phase 4 trial testing Pyridostigmine in Postdural Puncture Headache in 30 participants. Completed in 3 January 2024.
3 January 2024
Quick facts
| Lead sponsor | Ain Shams University |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 25 July 2023 |
| Primary completion | 3 January 2024 |
| Estimated completion | 3 January 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Pyridostigmine — full drug profile →
- Placebo
Conditions studied
- Postdural Puncture Headache — all drugs for Postdural Puncture Headache →
Sponsor
Ain Shams University
Who can join
Adults 20 to 40, any sex, with Postdural Puncture Headache. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postdural puncture headache (PDPH) is a major complication of neuraxial anesthesia that can occur following spinal anesthesia and with inadvertent Dural puncture during epidural anesthesia. The presence of Pyridostigmine in CSF would be expected to increase the level of acetylcholine in CSF and subsequently in the brain through inhibition of cholinesterase. The increased level of acetylcholine would produce cerebral vasoconstriction.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05969119
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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- NCT03261570 — Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS · EARLY_PHASE1 · completed
Other recruiting trials for Postdural Puncture Headache
Currently open trials in the same condition.
- NCT07075874 — Neutrophil to Lymphocyte Ratio and Postdural Headache · recruiting
Other Ain Shams University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05969119 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
- Last refreshed: 4 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05969119.
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