Last reviewed · How we verify
NCT05968209
The Impact of Probiotic Supplementation on General Well Being
NA trial testing Lab4P in Well-Being, Psychological in 173 participants. Completed in 15 April 2025.
15 April 2025
Quick facts
| Lead sponsor | Cwm Taf University Health Board (NHS) |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 173 |
| Start date | 16 September 2024 |
| Primary completion | 15 April 2025 |
| Estimated completion | 15 April 2025 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Lab4P
Conditions studied
- Well-Being, Psychological — all drugs for Well-Being, Psychological →
Sponsor
Cwm Taf University Health Board (NHS)
Who can join
Adults 18 to 60, any sex, with Well-Being, Psychological. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The health and wellbeing of any workforce is a core priority and taking steps to ensure the wellbeing of employees is an important part of everyday working life. Winter is a time of particular challenge and is linked to increased absenteeism. There is a growing awareness that probiotics (similar to the bacteria found in yogurts) can play a role in boosting general wellbeing. Probiotics are known as 'good' or 'friendly' bacteria and are living organisms that are found naturally in yogurt and fermented foods. They can be capsules, tablets or powders in sachets that are taken daily to help to keep the gut in peak condition. Everyone has trillions of bacteria in their guts living together happily and they are needed to boost our wellbeing but the stresses and strains of everyday life can often disturb their balance, probiotics can help to restore the balance. Over the winter of 2022, a small exploratory study with employees based in South Wales who were offered the opportunity to 'try out' a probiotic manufactured by Cultech Limited (a company based in Port Talbot specialising in the production of nutritional supplements). The results were very promising with significant improvements in wellbeing and reduced absenteeism among those who opted to take the product. This project is designed as a follow-up on last year's exploratory study to further assess effectiveness of the same probiotic nutritional supplement over the winter
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Impact of Probiotics on Wellbeing: An Open-Label study during the Winter in Healthcare Workers
Wright C, Goodwin C, John D, Michael D, et al · · 2025 · DOI 10.1101/2025.08.19.25333967
Verify or expand the search:
- PubMed search for NCT05968209
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Lab4P
Trials testing the same drug.
- NCT06507111 — The Impact of Probiotics on Well-being in Women · NA · completed
Other recruiting trials for Well-Being, Psychological
Currently open trials in the same condition.
- NCT07221422 — The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project · NA · recruiting
- NCT07240571 — Randomized Controlled Trial of a Family-focused Intervention for Caregivers and Young Adolescents (Phase 3 of FLOURISH) · NA · recruiting
- NCT06874790 — RCT for Latina Mental Health Using Web-Based Apps · NA · recruiting
- NCT07102017 — A Randomized Controlled Trial of Robotic Support for Enhanced Later Life (RoSELL) · NA · active not recruiting
- NCT06822777 — RISE for Nurse Preceptors · NA · active not recruiting
Other Cwm Taf University Health Board (NHS) trials
Trials by the same sponsor.
- NCT05645081 — Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke · recruiting
- NCT05171998 — Characterisation of the Immune Response to SARS-CoV-2 Infection / COVID-19 in Type 1 Diabetes · completed
- NCT04729452 — Characterisation of the Immune Response to SARS-CoV-2 / COVID-19 · completed
- NCT05391035 — The Antibiotic Guardian Study- Clinical Evaluation of a Novel, Rapid Diagnostic for Gonorrhoea and Mycoplasma Infections · completed
- NCT05186792 — Mycoplasma Species and the Genitourinary System · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05968209 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cwm Taf University Health Board (NHS)
- Last refreshed: 20 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05968209.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing