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NCT05964686
The Efficacy of Laser in Root Canal Disinfection
Phase 2 trial testing Conventional group (NaOCl/EDTA) in Pulp and Periapical Tissue Disease in 30 participants. Completed in 30 December 2022.
30 September 2022
Quick facts
| Lead sponsor | Future University in Egypt |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 January 2022 |
| Primary completion | 30 September 2022 |
| Estimated completion | 30 December 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Conventional group (NaOCl/EDTA)
- Dual laser group (Er,Cr:YSGG/Diode):
- Combined group (EDTA/Diode):
Conditions studied
- Pulp and Periapical Tissue Disease — all drugs for Pulp and Periapical Tissue Disease →
- Pulp Necroses — all drugs for Pulp Necroses →
- Pulp; Granuloma — all drugs for Pulp; Granuloma →
Sponsor
Future University in Egypt
Who can join
Adults 18 to 35, any sex, with Pulp and Periapical Tissue Disease or Pulp Necroses. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to assess in vivo the efficacy of Er,Cr:YSGG/diode laser and Diode/EDTA on bacterial count in root canal treatment in an evidence-based clinical trial. The null hypothesis being tested is that there is no difference in total bacterial count reduction between conventional irrigation and the two types of lasers used. Thirty patients are equally divided into 3 separate groups : * Group A (Conventional): 2.5% NaOCL and 17% EDTA. * Group B(Dual): saline along with Er,Cr:YSGG laser and diode laser combination * Group C(Combined): saline along with 17% EDTA and diode laser combination Microbiological analysis will be done for both aerobic and anaerobic bacteria using Colony forming units. All data will be collected, tabulated, summarized, and statistically analyzed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The efficacy of 2780 nm Er,Cr;YSGG and 940 nm Diode Laser in root canal disinfection: A randomized clinical trial.
Fahim SZ, Ghali RM, Hashem AA, Farid MM. · · 2024 · cited 10× · PMID 38403667 · DOI 10.1007/s00784-024-05563-z
Verify or expand the search:
- PubMed search for NCT05964686
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05964686 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Future University in Egypt
- Last refreshed: 29 November 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05964686.
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