Who is sponsoring NCT05961917?

NCT05961917 is sponsored by Bozyaka Training and Research Hospital.

What drugs are being tested in NCT05961917?

Interventions in NCT05961917: 5 cmH2O Positive end-expiratory pressure (PEEP), 10 cmH2O Positive end-expiratory pressure (PEEP).

What condition does NCT05961917 study?

NCT05961917 studies Regional Cerebral Oxygen Saturation.

Is NCT05961917 still recruiting?

NCT05961917 is currently completed. Last updated 13 August 2024.

Last reviewed 2024-08-13 · How we verify

NCT05961917

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Different Positive End Expiratory Pressures on Regional Cerebral Oxygen Saturation

Completed NA Last updated 13 August 2024

What this trial tests

NA trial testing 5 cmH2O Positive end-expiratory pressure (PEEP) in Regional Cerebral Oxygen Saturation in 64 participants. Completed in 15 November 2023.

Timeline

15 February 2023

Primary endpoint
15 October 2023

15 November 2023

Quick facts

Lead sponsor	Bozyaka Training and Research Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	screening
Enrollment	64
Start date	15 February 2023
Primary completion	15 October 2023
Estimated completion	15 November 2023
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

5 cmH2O Positive end-expiratory pressure (PEEP)
10 cmH2O Positive end-expiratory pressure (PEEP)

Conditions studied

Regional Cerebral Oxygen Saturation — all drugs for Regional Cerebral Oxygen Saturation →

Sponsor

Bozyaka Training and Research Hospital

Who can join

18 and older, any sex, with Regional Cerebral Oxygen Saturation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this prospective single-blind randomized clinical trial is to compare the effect of two different positive end expiratory pressure (PEEP) levels on regional cerebral oxygen saturation in patients scheduled for craniotomy due to supratentorial masses. The main question it aims to answer is that how high PEEP level effects the regional cerebral oxygen saturation in patients with high intracranial pressure due to mass effect. Patients will be divided into two groups as Group low PEEP (5 cmH2O) and Group high PEEP (10 cmH2O). Researchers will compare the changes of regional cerebral oxygen saturations between two groups by near infra-red spectroscopy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparative Analysis of 5 cmH₂O Versus 10 cmH₂O PEEP on Cerebral Oxygen Saturation in Brain Tumor Surgery: A Randomized Controlled Clinical Study.
Şahinkaya HH, Tabanli A, Ozgenc G, Ayar C, et al · · 2025 · PMID 40069960 · DOI 10.12659/msm.947379

Verify or expand the search:

Other recruiting trials for Regional Cerebral Oxygen Saturation

Currently open trials in the same condition.

NCT06855407 — Hypertension and Cerebrovascular Hemodynamics in General Anaesthesia · NA · recruiting

Other Bozyaka Training and Research Hospital trials

Trials by the same sponsor.

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NCT06984653 — Effect of Scalp Block on Bispectral Index Values During Skull Pinning · completed
NCT06759506 — Can Perfusion Index and Cerebral Oxygen Saturation Trends Predict Low Cardiac Output in Pediatric Cardiovascular Surgeri · not yet recruiting
NCT06430918 — Neuropathic Pain and it's Relation to Sleep Quality in Knee Osteoarthritis · enrolling by invitation
NCT06029413 — Myo vs. Myofascial Injection for Myofascial Trigger Points · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05961917 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Bozyaka Training and Research Hospital
Last refreshed: 13 August 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05961917.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing