NCT05959759 is a Phase 4 clinical trial of Dimethyl fumarate in Intracranial Aneurysm, sponsored by Beijing Tiantan Hospital.

Who is sponsoring NCT05959759?

NCT05959759 is sponsored by Beijing Tiantan Hospital.

What drugs are being tested in NCT05959759?

Interventions in NCT05959759: Dimethyl fumarate, Placebo.

What condition does NCT05959759 study?

NCT05959759 studies Intracranial Aneurysm, Aneurysm, Brain, Inflammation Vascular.

Is NCT05959759 still recruiting?

NCT05959759 is currently status unknown. Last updated 25 July 2023.

Last reviewed 2023-07-25 · How we verify

NCT05959759

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dimethyl Fumarate Treatment for Intracranial Unruptured Aneurysms.

Status unknown Phase 4 Last updated 25 July 2023

What this trial tests

Phase 4 trial testing Dimethyl fumarate in Intracranial Aneurysm in 60 participants. Status unknown.

Timeline

31 July 2023

Primary endpoint
31 December 2023

1 June 2024

Quick facts

Lead sponsor	Beijing Tiantan Hospital
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	60
Start date	31 July 2023
Primary completion	31 December 2023
Estimated completion	1 June 2024
Sites	1 location across China

Drugs / interventions tested

Dimethyl fumarate (DIMETHYL FUMARATE) — full drug profile →
Placebo

Conditions studied

Intracranial Aneurysm — all drugs for Intracranial Aneurysm →
Aneurysm, Brain — all drugs for Aneurysm, Brain →
Inflammation Vascular — all drugs for Inflammation Vascular →

Sponsor

Beijing Tiantan Hospital

Who can join

18 and older, any sex, with Intracranial Aneurysm or Aneurysm, Brain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study was designed to identify whether there is a measurable reduction in inflammation in walls of intracranial aneurysms with oral dimethyl fumarate.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases.
Cuadrado A, Cazalla E, Bach A, Bathish B, et al · · 2025 · cited 9× · PMID 40059038 · DOI 10.1016/j.redox.2025.103569
Time to Consider Pharmacologic Management of Unruptured Intracranial Aneurysms?
Kim YS, Hwang S, Kim MH, Kwon B, et al · · 2025 · PMID 40955112 · DOI 10.5853/jos.2025.01662
Dimethyl fumarate treatment for unruptured intracranial aneurysms: a study protocol for a double-blind randomised controlled trial.
Huang J, Zhang Y, Turhon M, Zheng Z, et al · · 2024 · PMID 38772883 · DOI 10.1136/bmjopen-2023-080333

Verify or expand the search:

Other trials of Dimethyl fumarate

Trials testing the same drug.

NCT06513533 — Dimethyl Fumarate in Adrenomyeloneuropathy · Phase 2, PHASE3 · recruiting
NCT05658484 — A Study of Dimethyl Fumarate (DMF) in Relapsing Forms of Multiple Sclerosis (RMS) Participants in China · Phase 4 · completed
NCT04890353 — Impact of an Immune Modulator Dimethyl Fumarate on Acute Ischemic Stroke · Phase 1, PHASE2 · terminated
NCT04890379 — Dimethyl Fumarate for the Treatment of Intracerebral Hemorrhage · Phase 2 · withdrawn
NCT04756687 — Real World Analysis on Lymphocyte Reconstitution After Lymphopenia in Participants Treated by Tecfidera · completed

Other recruiting trials for Intracranial Aneurysm

Currently open trials in the same condition.

NCT07123818 — AI for Detection of Brain Aneurysm: Low-cost Opportunistic Screening · NA · active not recruiting
NCT06494436 — Microvention AnEurysm & STroke Real-life Data cOllection · recruiting
NCT06588543 — Patient-specific Planning of Minimally Invasive Brain Interventions Based on Vascular-hemodynamic Mapping · recruiting
NCT05831202 — SEAL™IT: Saccular Endovascular Aneurysm Lattice System Interventional Pivotal Trial · Phase 3 · active not recruiting
NCT06416657 — General Anesthesia vs Local Anesthesia for Endovascular Treatment in Patients With Unruptured Intracranial Aneurysm Usin · NA · recruiting

Other Beijing Tiantan Hospital trials

Trials by the same sponsor.

NCT07341854 — Dexamethasone Palmitate for Postoperative Pain · NA · not yet recruiting
NCT07527013 — Stratified Blood Pressure Management Strategy After Endovascular Treatment for Acute Ischemic Stroke · Phase 3 · not yet recruiting
NCT07520370 — Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor · NA · not yet recruiting
NCT07526987 — Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis · Phase 3 · not yet recruiting
NCT07591207 — The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05959759 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beijing Tiantan Hospital
Last refreshed: 25 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05959759.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing