NCT05953662

Safety and Efficacy of Reduced-port Laparoscopic Surgery for Patients Of Colon and Upper Rectal Cancer

Active, enrolled NA Last updated 14 May 2025

What this trial tests

NA trial testing Reduced-port laparoscopic surgery in Colorectal Neoplasm in 500 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 September 2023

Primary endpoint
1 April 2025

1 April 2026

Quick facts

Lead sponsor	Sixth Affiliated Hospital, Sun Yat-sen University
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	500
Start date	1 September 2023
Primary completion	1 April 2025
Estimated completion	1 April 2026
Sites	1 location across China

Drugs / interventions tested

• Reduced-port laparoscopic surgery
• conventional laparoscopic surgery

Conditions studied

• Colorectal Neoplasm — all drugs for Colorectal Neoplasm →

Sponsor

Sixth Affiliated Hospital, Sun Yat-sen University

Who can join

Adults 18 to 80, any sex, with Colorectal Neoplasm. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Colorectal cancer is the third most common malignant tumor. Radical resection is the mainstay of treatments for non-metastatic colorectal cancer. In case of traditional laparoscopic surgery, inexperienced assistants are likely to cause side injuries and interfere surgeon due to limited operating space. Reduced-port laparoscopic surgery has only 3 ports for surgeon and observer, and the surgeon completes the surgery independently, which increases the difficulty of the operation. However, reduced-port laparoscopy has some potential advantages and applications. Reduced-port laparoscopic surgery avoids the prolongation of the operation time and parainjury caused by inexperienced assistant. Reduced-port laparoscopy reduces some surgical incisions, resulting in less pain and faster recovery. Reduced-port laparoscopy also reduces the consumables, human resources and medical expenses. This study aims to evaluate the curative effect and safety of reduced-port laparoscopic surgery versus conventional laparoscopic surgery for resectable colorectal cancer.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Efficacy and safety of reduced-port laparoscopic surgery versus conventional laparoscopic surgery for colorectal cancer.
   Liu ZM, Yao QJ, Pei F, He F, et al · · 2025 · PMID 39893372 · DOI 10.1186/s12885-025-13585-3