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NCT05953558: AV-CESAR
French Cohort Evaluating the effectiveneSs of Atrioventricular Synchrony by the micRa AV
trial testing Patients implanted with Micra AV in Atrioventricular Synchrony by the Micra AV in 1,000 participants. Currently enrolling.
1 November 2023
Quick facts
| Lead sponsor | Paris Sudden Death Expertise Center |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 1 May 2023 |
| Primary completion | 1 November 2023 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across France |
Drugs / interventions tested
- Patients implanted with Micra AV
Conditions studied
- Atrioventricular Synchrony by the Micra AV — all drugs for Atrioventricular Synchrony by the Micra AV →
Sponsor
Paris Sudden Death Expertise Center
Who can join
Adults 18 to 110, any sex, with Atrioventricular Synchrony by the Micra AV. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Transvenous cardiac pacemakers have pitfalls due to lead- and device pocket-related complications. Leadless pacemakers were developed and introduced into clinical practice to overcome the weaknesses of traditional transvenous pacemakers. The absence of atrial pacing has restricted their uses mainly for cases of paroxysmal atrioventricular block (AVB) or AVB with atrial fibrillation. The Micra AV contains an embedded accelerometer that senses the atrial contraction waveform, allowing the ventricle to be paced once the atrial contraction is complete. This atrioventricular synchronization is intended to extend the use of the device to cases of permanent complete AVB with normal sinus function. Two randomized clinicals trials have been proven it's efficacy. However, with AV-CESAR cohort, we aim to evaluate the real word effectiveness of Micra AV, in the first 1000 patients implanted by the device in France.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
One-Year Outcomes of the First 1000 Patients Implanted With the Medtronic Micra AV Leadless Pacing System in France: The AV-CESAR Cohort Study.
Kerkouri F, Clementy N, Defaye P, Ait Said M, et al · · 2026 · PMID 42159009 · DOI 10.1161/circep.126.014850
Verify or expand the search:
- PubMed search for NCT05953558
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other Paris Sudden Death Expertise Center trials
Trials by the same sponsor.
- NCT06739239 — French COhoRte Extra-Vascular Implantable CardiovErter DefibrillatoR · recruiting
- NCT05302115 — S-ICD French Cohort Study (HONEST) · unknown
- NCT03837574 — French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05953558 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Paris Sudden Death Expertise Center
- Last refreshed: 20 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05953558.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing