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NCT05953038: dOccLS
LSD Occupancy of the Serotonin 2A Receptor in the Human Brain
EARLY_PHASE1 trial testing Lysergic Acid Diethylamide Tartrate in Basic Science in 40 participants. Participants enrolled and being followed up; not accepting new ones.
18 December 2027
Quick facts
| Lead sponsor | Rigshospitalet, Denmark |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 8 November 2023 |
| Primary completion | 18 December 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Lysergic Acid Diethylamide Tartrate — full drug profile →
Conditions studied
- Basic Science — all drugs for Basic Science →
Sponsor
Rigshospitalet, Denmark
Who can join
Adults 18 to 75, any sex, with Basic Science. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators wish to quantify the relation between administered dose of lysergic acid diethylamide (LSD), plasma LSD levels, and occupancy at the serotonin 2A receptor (5-HT2AR) using \[11C\]CIMBI-36 positron emission tomography.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Absolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double-Blind, Placebo-Controlled, Crossover Study.
Arikci D, Holze F, Mueller L, Vizeli P, et al · · 2025 · cited 1× · PMID 40418105 · DOI 10.1002/cpt.3726 -
Molecular, haemodynamic and functional effects of LSD in the human brain
McCulloch DE, Larsen K, Johansen A, Reveles Jensen KH, et al · · 2025 · DOI 10.1101/2025.06.17.25329677
Verify or expand the search:
- PubMed search for NCT05953038
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Basic Science
Currently open trials in the same condition.
- NCT05374460 — Factors Affecting Sensory and Motor Learning · NA · recruiting
- NCT03289949 — The Neurobiological Effect of 5-HT2AR Modulation · Phase 1 · recruiting
Other Rigshospitalet, Denmark trials
Trials by the same sponsor.
- NCT07401368 — Clinicians' Trust in AI-Based Fetal Growth Estimates · NA · not yet recruiting
- NCT07442357 — The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial · NA · not yet recruiting
- NCT07528729 — Alcohol as a Modifiable Risk Factor for Atrial Fibrillation · NA · not yet recruiting
- NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
- NCT07467187 — Invasive Home Ventilation in Denmark · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05953038 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
- Last refreshed: 18 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05953038.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing