NCT05952895

Salivary Proteome in Response to Non-surgical Periodontal Treatment

Completed Last updated 19 July 2023

What this trial tests

trial testing Conventional quadrant-wise scaling and root planing (SRP) in Periodontitis in 10 participants. Completed in 30 December 2019.

Timeline

1 July 2018

Primary endpoint
30 June 2019

30 December 2019

Quick facts

Lead sponsor	Aydin Adnan Menderes University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	10
Start date	1 July 2018
Primary completion	30 June 2019
Estimated completion	30 December 2019
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Conventional quadrant-wise scaling and root planing (SRP)

Conditions studied

• Periodontitis — all drugs for Periodontitis →

Sponsor

Aydin Adnan Menderes University

Who can join

Adults 32 to 43, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to investigate salivary proteome changes in periodontitis patients before and after non-surgical treatment. Ten systemically healthy and non-smoker individuals with stage III, grade C periodontitis underwent non-surgical periodontal treatment. Saliva was collected at baseline, and one and six months post-treatment. Whole-mouth plaque and gingival index, probing depth, bleeding on probing and clinical attachment loss were measured. The saliva proteome was investigated by label-free quantitative proteomics. Normalized protein intensities were measured and protein changes were modeled over time with significant protein regulation considered at false discovery rate (FDR)\<0.05.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Probing the salivary proteome for prognostic biomarkers in response to non-surgical periodontal therapy.
   Silbereisen A, Bao K, Wolski W, Nanni P, et al · · 2025 · cited 9× · PMID 38660744 · DOI 10.1111/jcpe.13990