Last reviewed · How we verify
NCT05952427: ACESI
Adverse Childhood Experiences and Infertility : ACESI
trial testing ACE Questionnaire in Infertility, Female in 332 participants. Status unknown.
1 August 2023
Quick facts
| Lead sponsor | University Hospital, Grenoble |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 332 |
| Start date | 1 August 2023 |
| Primary completion | 1 August 2023 |
| Estimated completion | 1 July 2024 |
Drugs / interventions tested
- ACE Questionnaire
Conditions studied
- Infertility, Female — all drugs for Infertility, Female →
- Trauma, Psychological — all drugs for Trauma, Psychological →
- Child Development — all drugs for Child Development →
- Child Abuse — all drugs for Child Abuse →
Sponsor
University Hospital, Grenoble
Who can join
Adults 18 to 43, female only, with Infertility, Female or Trauma, Psychological. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Adverse childhood experiences can have powerful effects on health and quality of life in adulthood. Thus, having a history of childhood trauma, before the age of 18 (physical aggression, sexual abuse, death of a close person, etc.) significantly increases the risk of having cancer, cardiovascular disease, psychological damage , or earlier mortality. Validated scores allow the evaluation of the importance of adverse childhood experiences, in particular the ACE score (adverse childhood experiences) published by Felitti. Studies on the subject show a dose-response relationship between exposure to adverse childhood experiences and negative outcomes in terms of health and well-being. The physiopathological tracks to explain the occurrence of somatic pathologies in adulthood include the observation of a state of hyper-activation of the HPA axis that persists in adulthood; modulations of immunity, but also epigenetic modifications. Some data are available on the associations between childhood trauma and obstetric risks, with a significant increase in the risk of preterm delivery and fetal death in utero. Primary objective : 1a) To study the prevalence of adverse childhood experiences (ACE) in women consulting for the first time in an PMA service for the desire to become pregnant, and 1b) To study the association between adverse childhood experiences and infertility in adulthood, by comparing infertile women with nulliparous control women in the general population consulting for their classic gynecological follow-up.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05952427
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05952427 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Grenoble
- Last refreshed: 19 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05952427.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing