NCT05951712 (SIMETHICONE) is a NA clinical trial of Simethicone 150mg in Mucosal Erosion, sponsored by Asian Institute of Gastroenterology, India.

Who is sponsoring NCT05951712?

NCT05951712 is sponsored by Asian Institute of Gastroenterology, India.

What drugs are being tested in NCT05951712?

Interventions in NCT05951712: Simethicone 150mg, N Acetyl cysteine 600mg, Simethicone 150mg plus N Acetyl cysteine 600 mg, Placebo.

What condition does NCT05951712 study?

NCT05951712 studies Mucosal Erosion.

Is NCT05951712 still recruiting?

NCT05951712 is currently completed. Last updated 24 July 2023.

Last reviewed 2023-07-24 · How we verify

NCT05951712: SIMETHICONE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pre-medication With N-acetylcysteine and Simethicone to Improve Mucosal Visibility During Gastroduodenoscopy

Completed NA Last updated 24 July 2023

What this trial tests

NA trial testing Simethicone 150mg in Mucosal Erosion in 800 participants. Completed in 4 November 2022.

Timeline

16 June 2022

Primary endpoint
20 August 2022

4 November 2022

Quick facts

Lead sponsor	Asian Institute of Gastroenterology, India
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	diagnostic
Enrollment	800
Start date	16 June 2022
Primary completion	20 August 2022
Estimated completion	4 November 2022
Sites	1 location across India

Drugs / interventions tested

Simethicone 150mg — full drug profile →
N Acetyl cysteine 600mg — full drug profile →
Simethicone 150mg plus N Acetyl cysteine 600 mg — full drug profile →
Placebo

Conditions studied

Mucosal Erosion — all drugs for Mucosal Erosion →

Sponsor

Asian Institute of Gastroenterology, India

Who can join

Adults 18 to 80, any sex, with Mucosal Erosion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this study, we aimed to compare combined premedication with simethicone or N-acetylcysteine (NAC) for mucosal visualisation during esophagogastroduodenoscopy (EGD). The primary outcome of the study was comparison of total mucosal visibility score (TMVS) between combined pre-medication (Simethicone+ NAC) and individual pre-medication groups (Simethicone and NAC) in patients undergoing EGD. Secondary outcomes included comparison of TMVS between different groups, TMVS in early (10-20 min) versus late (\>20-30 min) endoscopy groups, adequate gastric mucosal visibility, detection of lesions and adverse events related to the pre-medications. Adequate and inadequate gastric mucosal visibility was defined as a cumulative score of \<7 and ≥7, respectively.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Pre-medication with simethicone and N-acetyl cysteine for improving mucosal visibility during upper gastrointestinal endoscopy: A randomized controlled trial.
Nabi Z, Vamsi M, Goud R, Sayyed M, et al · · 2024 · cited 6× · PMID 37848768 · DOI 10.1007/s12664-023-01459-0

Verify or expand the search:

Other Asian Institute of Gastroenterology, India trials

Trials by the same sponsor.

NCT07486518 — A Multicentre Prospective Cohort Study of The Gastric Precancerous Epithelial Pathway Using High-Definition Endoscopy An · not yet recruiting
NCT07413822 — A Single-centre Open, Prospective, Pilot Clinical Study to Assess the Safety and Performance of the TIES® Transcutaneous · NA · not yet recruiting
NCT07399652 — Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures · NA · recruiting
NCT07371832 — A Single Center Evaluation of AI Enabled SureForm Robotic Stapler (SureformTM) Compared to Conventional Stapler for Colo · recruiting
NCT07329816 — External, Multicentre Validation of a Machine-Learning Model to Predict Colonic Adenoma in Indian Adults · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05951712 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Asian Institute of Gastroenterology, India
Last refreshed: 24 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05951712.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing