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NCT05947370
Berberine on the Secretion of Incretin
EARLY_PHASE1 trial testing Berberine Chloride in Diabetes Mellitus in 16 participants. Completed in 20 April 2023.
6 April 2023
Quick facts
| Lead sponsor | Beijing Tongren Hospital |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 16 |
| Start date | 12 October 2022 |
| Primary completion | 6 April 2023 |
| Estimated completion | 20 April 2023 |
| Sites | 2 locations across China |
Drugs / interventions tested
- Berberine Chloride — full drug profile →
- Placebo
Conditions studied
- Diabetes Mellitus — all drugs for Diabetes Mellitus →
Sponsor
Beijing Tongren Hospital
Who can join
Adults 18 to 45, male only, with Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Berberine (BBR) is the main active ingredient of the ancient Chinese herb medicine Coptis. The hypoglycemic effect of BBR has been demonstrated in numerous studies. Although BBR is safe and effective in the treatment of diabetes, its exact hypoglycemic mechanism is still unclear. Jin-Kui Yang found that BBR can promote GLP-1 secretion from intestinal L cells in mice in vitro and in vivo, thereby achieving the effect of lowering blood glucose, but it is still unknown whether BBR can promote incretin secretion in humans. In this study, investigators plan to examine the effect of BBR on secretion of incretin in human.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05947370
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other trials of Berberine Chloride
Trials testing the same drug.
- NCT03972215 — Berberine Hyperglycemic Clamp · EARLY_PHASE1 · completed
- NCT02365480 — Berberine Chloride in Preventing Colorectal Cancer in Patients With Ulcerative Colitis in Remission · Phase 1 · completed
Other recruiting trials for Diabetes Mellitus
Currently open trials in the same condition.
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- NCT07425275 — Integrated Oral Care Intervention for Xerostomia in Diabetes Patients · NA · recruiting
- NCT06918977 — Improving Glycemic Control With Telemedicine and Smart Insulin Pens · NA · recruiting
Other Beijing Tongren Hospital trials
Trials by the same sponsor.
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- NCT07523737 — Pomalidomide, Anti-PD-1 Antibody Combined With Selinexor (PPS) in Relapsed/Refractory Primary Central Nervous System Dif · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05947370 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beijing Tongren Hospital
- Last refreshed: 17 July 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05947370.
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