Who is sponsoring NCT05947175?

NCT05947175 is sponsored by Istituto Ortopedico Rizzoli.

What drugs are being tested in NCT05947175?

Interventions in NCT05947175: Vertebral bone marrow (vBMA) clot, Bone allograft chips.

What condition does NCT05947175 study?

NCT05947175 studies Degenerative Spine Diseases.

Is NCT05947175 still recruiting?

NCT05947175 is currently recruiting now. Last updated 26 March 2025.

Last reviewed 2025-03-26 · How we verify

NCT05947175

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Vertebral Bone Marrow Clot for Spinal Surgery

Recruiting now NA Last updated 26 March 2025

What this trial tests

NA trial testing Vertebral bone marrow (vBMA) clot in Degenerative Spine Diseases in 96 participants. Currently enrolling.

Timeline

19 May 2023

Primary endpoint
31 December 2025

18 May 2026

Quick facts

Lead sponsor	Istituto Ortopedico Rizzoli
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	96
Start date	19 May 2023
Primary completion	31 December 2025
Estimated completion	18 May 2026
Sites	1 location across Italy

Drugs / interventions tested

Vertebral bone marrow (vBMA) clot — full drug profile →
Bone allograft chips

Conditions studied

Degenerative Spine Diseases — all drugs for Degenerative Spine Diseases →

Sponsor

Istituto Ortopedico Rizzoli — full company profile →

Who can join

Adults 18 to 80, any sex, with Degenerative Spine Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Spinal fusion (SF) is a common orthopedic procedure to treat spinal diseases. Apart from fixation systems, the procedure requires bone grafting to further improve SF. Cell-based therapies as vertebral bone marrow aspirate (vBMA) with bone allograft were developed as alternative to bone autograft in SF. However, vBMA use is limited by the lack of a standardized procedure, of a structural texture and by the possibility of diffusion away from the implant site. Recently, the potential use of a new formulation of vBMA, named vBMA clot, has been described. The project aims at evaluating the clinical evidence and the biological features of vBMA clot associated to bone allograft for SF surgery, considering age and gender related differences. A randomized controlled trial will prove the efficacy of the treatment and advanced preclinical studies will improve the knowledge on vBMA clot regenerative and anti-inflammatory properties, exploring for the first time its antibacterial characteristics.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial.
Sartori M, Tedesco G, Spinnato P, Mazzotti A, et al · · 2025 · PMID 40417680 · DOI 10.3389/fmed.2025.1591041

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05947175 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Istituto Ortopedico Rizzoli
Last refreshed: 26 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05947175.

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