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Assessing the Longitudinal Outcomes of Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA): a Randomized Controlled Trial
This study is an internal pilot for a multicenter, blinded randomized controlled trial. The purpose of the multicenter trial is to determine whether post-operative piperacillin/tazobactam is more effective than ceftriaxone and metronidazole for children treated with laparoscopic appendectomy for perforated appendicitis. We plan to conduct an internal pilot study to determine whether a blinded multicenter randomized controlled trial is feasible.
Details
| Lead sponsor | McMaster Children's Hospital |
|---|---|
| Phase | Phase 2 |
| Status | UNKNOWN |
| Enrolment | 16 |
| Start date | 2024-01 |
| Completion | 2024-12 |
Conditions
- Appendicitis Perforated
Interventions
- Piperacillin/tazobactam
- Normal saline
- CefTRIAXone Injection
- Metronidazole Injection
Primary outcomes
- Length of stay — Index admission
Length of stay in hospital during index admission