NCT05940207

Safety Testing of Hydrogen Peroxide-Generating e-Bandage on Normal Human Skin

Active, enrolled NA Last updated 22 January 2026

What this trial tests

NA trial testing e-Bandages in Healthy in 40 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

27 March 2024

Primary endpoint
1 May 2029

1 May 2029

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	other
Enrollment	40
Start date	27 March 2024
Primary completion	1 May 2029
Estimated completion	1 May 2029
Sites	1 location across United States

Drugs / interventions tested

• e-Bandages

Conditions studied

• Healthy — all drugs for Healthy →

Sponsor

Mayo Clinic

Who can join

Adults 18 to 99, any sex, with Healthy. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• e-Bandage Discomfort
  Time frame: Approximately 3 - 24 hours
  Self-report discomfort with the e-Bandage, graded on a scale of 1-4, with 1 being no reaction, 2 mild reaction, 3 moderate reaction, 4 severe reaction.
• Skin irritation/dermatitis
  Time frame: Approximately 3 - 24 hours
  Skin redness or swelling, graded on a scale of 1-4, with 1 being no reaction, 2 mild reaction, 3 moderate reaction, 4 severe reaction.
• Allergic Reaction
  Time frame: Approximately 3 - 24 hours
  Local/systemic allergic reaction to the e-Bandage, graded on a scale of 1-4, with 1 being no reaction, 2 mild reaction, 3 moderate reaction, 4 severe reaction.
• Skin Discoloration
  Time frame: Approximately 3 - 24 hours
  Skin discoloration from the e-Bandage, graded on a scale of 1-4, with 1 being no reaction, 2 mild reaction, 3 moderate reaction, 4 severe reaction.

Sponsor's own description

A novel hydrogen peroxide-generating electrochemical bandage for wound infection treatment and prevention, and wound healing has been developed. The purpose of this research is to gather information on the safety and to confirm lack of toxicity of small hydrogen peroxide-generating e-bandages on normal human skin.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Safety trial assessing 1.77 cm<sup>2</sup> H<sub>2</sub>O<sub>2</sub> producing electrochemical bandages on healthy human skin.
   Kies PJ, Kim WJ, Fleming D, Bozyel I, et al · · 2025 · PMID 41168214 · DOI 10.1038/s41598-025-21803-y