NCT05932836

An Organoid-on-chips Technique Based on Biopsy Samples and Its Efficacy in Predicting the Response to HAI in HCC

Active, enrolled Last updated 22 January 2025

What this trial tests

trial testing No interventions. in Hepatocellular Carcinoma in 165 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 March 2023

Primary endpoint
31 December 2024

30 September 2025

Quick facts

Lead sponsor	Xiangya Hospital of Central South University
Status	Active, enrolled
Study type	OBSERVATIONAL
Enrollment	165
Start date	1 March 2023
Primary completion	31 December 2024
Estimated completion	30 September 2025
Sites	1 location across China

Drugs / interventions tested

• No interventions.

Conditions studied

• Hepatocellular Carcinoma — all drugs for Hepatocellular Carcinoma →

Sponsor

Xiangya Hospital of Central South University

Who can join

Adults 18 to 75, any sex, with Hepatocellular Carcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is aimed to establish an organoid-on-chips technological system based on biopsy samples and evaluate its efficacy in predicting the response to mFOLFOX6 infusion in patients with hepatocellular carcinoma (HCC).

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine.
   Yao Q, Cheng S, Pan Q, Yu J, et al · · 2024 · cited 40× · PMID 39309690 · DOI 10.1002/mco2.735
2. Liver organoids: Current advances and future applications for hepatology.
   Kim Y, Kang M, Mamo MG, Adisasmita M, et al · · 2025 · cited 7× · PMID 39722609 · DOI 10.3350/cmh.2024.1040
3. The application of organoids in treatment decision-making for digestive system cancers: progress and challenges.
   Wang Y, Zhang L, Wang LZ, Cao Y, et al · · 2025 · cited 4× · PMID 40855314 · DOI 10.1186/s12943-025-02429-0
4. Human patient derived organoids: an emerging precision medicine model for gastrointestinal cancer research.
   Yan S, He Y, Zhu Y, Ye W, et al · · 2024 · cited 4× · PMID 38638528 · DOI 10.3389/fcell.2024.1384450
5. Exploring bone-tumor interactions through 3D <i>in vitro</i> models: Implications for primary and metastatic cancers.
   Cristini N, Tavakoli M, Sanati M, Yavari SA. · · 2025 · cited 3× · PMID 40606222 · DOI 10.1016/j.jbo.2025.100698
6. Organoid as a promising tool for primary liver cancer research: a comprehensive review.
   Hu X, Wei J, Liu P, Zheng Q, et al · · 2024 · cited 3× · PMID 39192365 · DOI 10.1186/s13578-024-01287-5
7. Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges.
   Jiao C, Karakaya OF, Dadgar N, Wehrle CJ, et al · · 2026 · PMID 41503024 · DOI 10.1002/mco2.70571
8. Application of stem cells in the precise diagnosis and treatment of liver diseases.
   Wang YX, Ren YN, Zhang SS, Sun S, et al · · 2025 · PMID 41479645 · DOI 10.3748/wjg.v31.i46.114415