NCT05932823

Does the Type of Ventilation Affect the Risk for Infections After Hip Replacements?

Completed Last updated 6 July 2023

What this trial tests

trial testing Laminary airflow in Hip Prosthesis Infection in 110,000 participants. Completed in 31 December 2021.

Timeline

1 January 2010

Primary endpoint
31 December 2021

31 December 2021

Quick facts

Lead sponsor	University Hospital Bispebjerg and Frederiksberg
Status	Completed
Study type	OBSERVATIONAL
Enrollment	110,000
Start date	1 January 2010
Primary completion	31 December 2021
Estimated completion	31 December 2021

Drugs / interventions tested

• Laminary airflow

Conditions studied

• Hip Prosthesis Infection — all drugs for Hip Prosthesis Infection →

Sponsor

University Hospital Bispebjerg and Frederiksberg

Who can join

18 and older, any sex, with Hip Prosthesis Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: During hip replacement surgery, there is a risk that bacteria in the operating room can cause an infection. To try and reduce this risk, some operating rooms use a special system called laminar airflow (LAF), which reduces the number of bacteria in the air. However, it's not clear if LAF is better than the older system, called turbulent airflow (TAF), for preventing infections.

Aim: The aim of this study is to compare the two airflow systems and see if LAF is better at preventing infections after hip replacement surgery.

Methods: Information from a database containing all hip replacement surgeries done in Denmark between 2010 and 2020 is examined. The number of infections that occur in surgeries done with LAF, which reduces the number of bacteria in the air during surgery, is compared to the number of infections that occur in surgeries done with TAF. To make the results more credible, the data from the hip register was combined with data from the bacterial cultures taken during surgery.

Use and relevance: Infections after hip replacement surgery can be very serious and expensive to treat. Hospitals need to choose the best airflow system to help prevent these infections. This study is important because it gives more accurate information about which system is better at preventing infections and can help hospitals make better choices when they are designing or renovating operating rooms.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The association between laminar vs turbulent airflow and prosthetic hip joint infections: a prospective nationwide study from the Danish Hip Arthroplasty Register.
   Svensson JM, Andreasen AH, Solem EJ, Overgaard S. · · 2025 · PMID 41040053 · DOI 10.2340/17453674.2025.44356