NCT05928689 (Miso Prop) is a EARLY_PHASE1 clinical trial of Propranolol Hydrochloride tablet in Misophonia, sponsored by Icahn School of Medicine at Mount Sinai.

Who is sponsoring NCT05928689?

NCT05928689 is sponsored by Icahn School of Medicine at Mount Sinai.

What drugs are being tested in NCT05928689?

Interventions in NCT05928689: Propranolol Hydrochloride tablet, Reminder, Counterconditioning, Placebo.

What condition does NCT05928689 study?

NCT05928689 studies Misophonia.

Is NCT05928689 still recruiting?

NCT05928689 is currently completed. Last updated 16 October 2024.

Last reviewed 2024-10-16 · How we verify

NCT05928689: Miso Prop

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Behavioral and Pharmacological Reconsolidation Interference in Misophonia

Completed EARLY_PHASE1 Last updated 16 October 2024

What this trial tests

EARLY_PHASE1 trial testing Propranolol Hydrochloride tablet in Misophonia in 141 participants. Completed in 30 September 2024.

Timeline

2 June 2023

Primary endpoint
30 September 2024

30 September 2024

Quick facts

Lead sponsor	Icahn School of Medicine at Mount Sinai
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	other
Enrollment	141
Start date	2 June 2023
Primary completion	30 September 2024
Estimated completion	30 September 2024
Sites	1 location across United States

Drugs / interventions tested

Propranolol Hydrochloride tablet
Reminder
Counterconditioning
Placebo

Conditions studied

Misophonia — all drugs for Misophonia →

Sponsor

Icahn School of Medicine at Mount Sinai

Who can join

Adults 18 to 55, any sex, with Misophonia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

One of the core processes presumably underlying misophonia - a condition characterized by decreased tolerance for specific sounds - is associative learning. Using behavioral, computational, and neural analyses of emotional learning and memory processes to understand the unknown behavioral and neural mechanisms underlying misophonia's associative learning and memory, the study team will evaluate whether interference with the reconsolidation of a reactivated misophonia memory with propranolol can alleviate aversive reaction to misophonia-related cues.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Misophonia

Currently open trials in the same condition.

NCT07271485 — Propranolol for Misophonia · EARLY_PHASE1 · recruiting
NCT06960083 — Transcranial Magnetic Stimulation in Misophonia · NA · recruiting
NCT07527780 — Prevalence of Misophonia and Hyperacusis Among Teachers · recruiting
NCT07469033 — Prevalence of Misophonia in Turkish High School Students · recruiting
NCT06493825 — Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia · NA · recruiting

Other Icahn School of Medicine at Mount Sinai trials

Trials by the same sponsor.

NCT07094308 — The LIFT-ECHO Last Mile Project · NA · not yet recruiting
NCT07291427 — Chronic Subdural Hematoma Embolization With Detachable Coils · not yet recruiting
NCT07194187 — High Intensity Focused Ultrasound (HIFU) Ablation for Treatment of Prostate Tissue in Bladder Outlet Obstruction · NA · not yet recruiting
NCT07260916 — Minimally Invasive Neuroendoscopic Ultra-Early Targeted ICH Evacuation · NA · not yet recruiting
NCT07487948 — Safety and Biomarker Responses of Delgocitinib (JAK1,2,3/TYK2 Inhibitor) in Central Centrifugal Cicatricial Alopecia and · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05928689 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai
Last refreshed: 16 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05928689.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing