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NCT05927233
Effect of Methylprednisolone on Systemic Inflammatory Response During Pediatric Congenital Open-Heart Surgery
Phase 4 trial testing Methylprednisolone in Cyanotic Heart Disease in 60 participants. Currently enrolling.
30 April 2025
Quick facts
| Lead sponsor | Aga Khan University |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 60 |
| Start date | 1 April 2023 |
| Primary completion | 30 April 2025 |
| Estimated completion | 30 June 2025 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- Methylprednisolone (methylprednisolone) — full drug profile →
- Saline
Conditions studied
- Cyanotic Heart Disease — all drugs for Cyanotic Heart Disease →
- Cardiopulmonary Bypass — all drugs for Cardiopulmonary Bypass →
Sponsor
Aga Khan University
Who can join
Adults 1 Month to 18, any sex, with Cyanotic Heart Disease or Cardiopulmonary Bypass. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study is to evaluate the effects of steroids on the early postoperative inflammatory response in patients undergoing elective pediatric congenital cardiac surgery, requiring cardiopulmonary bypass (CPB).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05927233
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT07507643 — A Study of Methylprednisolone in People Having Liver Surgery · Phase 3 · recruiting
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Other recruiting trials for Cyanotic Heart Disease
Currently open trials in the same condition.
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Other Aga Khan University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05927233 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Aga Khan University
- Last refreshed: 31 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05927233.
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