NCT05927038 is a NA clinical trial of Caffeinated coffee in Healthy, sponsored by University College Cork.

Who is sponsoring NCT05927038?

NCT05927038 is sponsored by University College Cork.

What drugs are being tested in NCT05927038?

Interventions in NCT05927038: Caffeinated coffee, Decaffeinated coffee.

Is NCT05927038 still recruiting?

NCT05927038 is currently completed. Last updated 3 July 2023.

Last reviewed 2023-07-03 · How we verify

NCT05927038

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Coffee Consumption, the Gut Microbiome, and the Microbiota-Gut-Brain Axis

Completed NA Last updated 3 July 2023

What this trial tests

NA trial testing Caffeinated coffee in Healthy in 31 participants. Completed in 18 January 2023.

Timeline

21 September 2021

Primary endpoint
18 January 2023

18 January 2023

Quick facts

Lead sponsor	University College Cork
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	basic science
Enrollment	31
Start date	21 September 2021
Primary completion	18 January 2023
Estimated completion	18 January 2023
Sites	1 location across Ireland

Drugs / interventions tested

Caffeinated coffee
Decaffeinated coffee

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

University College Cork

Who can join

Adults 30 to 50, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study is to investigate the potential of coffee to act as a prebiotic to alter gut microbiota and improve mood, memory and cognitive performance.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Restoring Gut-brain Function by Medicinal Herbs Offering Neuroprotection through Suppressing Inflammatory Pathways: A Systematic Review.
Abbaszadeh F, Fakhri S, Varnamkhasti BS, Moradi SZ, et al · · 2025 · cited 1× · PMID 40457973 · DOI 10.2174/011570159x353541250128101649
Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition.
Boscaini S, Bastiaanssen TFS, Moloney GM, Bergamo F, et al · · 2026 · PMID 42014402 · DOI 10.1038/s41467-026-71264-8

Verify or expand the search:

Other trials of Caffeinated coffee

Trials testing the same drug.

NCT06754748 — Acute Effects of Caffeinated and Decaffeinated Coffee on Bioelectrical Impedance Analysis · NA · completed

Other recruiting trials for Healthy

Currently open trials in the same condition.

NCT06707207 — Predicting Future Errors During Skill Performance · recruiting
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NCT07499414 — The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease. · NA · recruiting
NCT07496697 — Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects · NA · recruiting
NCT06431932 — Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity · Phase 1, PHASE2 · recruiting

Other University College Cork trials

Trials by the same sponsor.

NCT07481240 — A Household-Based Dietary Intervention Study of Vitamin D Fortified Bread in Irish Families · NA · recruiting
NCT06857539 — Assessing Intellectual and Motor Outcomes in High-risk Infants · not yet recruiting
NCT07363928 — A Digital Cognitive Behavioural Therapy for Insomnia Intervention in Mild Cognitive Impairment and Mild Dementia · NA · completed
NCT06705582 — OASIS Study: Vitamin D Deficiency Prevention Among Older Adults in Ireland · NA · completed
NCT06709209 — AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05927038 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University College Cork
Last refreshed: 3 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05927038.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing