Who is sponsoring NCT05926297?

NCT05926297 is sponsored by Federico II University.

What drugs are being tested in NCT05926297?

Interventions in NCT05926297: Application NaOCl gel + HA gel, Non-surgical mechanical debridement.

What condition does NCT05926297 study?

NCT05926297 studies Peri-implant Mucositis, Mucositis Oral.

Is NCT05926297 still recruiting?

NCT05926297 is currently completed. Last updated 24 December 2025.

Last reviewed 2025-12-24 · How we verify

NCT05926297

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Peri-implant Mucositis by Sodium Hypochlorite Gel and Cross-linked Hyaluronic Acid Gel

Completed NA Last updated 24 December 2025

What this trial tests

NA trial testing Application NaOCl gel + HA gel in Peri-implant Mucositis in 92 participants. Completed in 1 July 2025.

Timeline

6 June 2023

Primary endpoint
1 July 2025

1 July 2025

Quick facts

Lead sponsor	Federico II University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	92
Start date	6 June 2023
Primary completion	1 July 2025
Estimated completion	1 July 2025
Sites	2 locations across Italy, Hungary

Drugs / interventions tested

Application NaOCl gel + HA gel
Non-surgical mechanical debridement

Conditions studied

Peri-implant Mucositis — all drugs for Peri-implant Mucositis →
Mucositis Oral — all drugs for Mucositis Oral →

Sponsor

Federico II University

Who can join

Adults 18 to 70, any sex, with Peri-implant Mucositis or Mucositis Oral. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the study is to evaluate the potential of the combination of a sodium hypochlorite-based gel and a hyaluronic acid-based gel as an adjuvant to Non-Surgical Mechanical Debridement (NSMD) in the treatment of mucositis, after 6 months of follow-up. After a meticulous selection, patients will be randomly assigned to Test (Sodium Hypochlorite-based gel + NSMD + Hyaluronic Acid-based gel ) or Control (NSMD) group. All clinical parameters will be recorded and the final evaluation will be performed.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Non-Surgical Submarginal Instrumentation of Peri-Implant Mucositis With Delivery of Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid: A Randomized Clinical Trial.
Iorio-Siciliano V, Blasi A, Mauriello L, Windisch P, et al · · 2026 · PMID 41761442 · DOI 10.1111/clr.70109

Verify or expand the search:

Other recruiting trials for Peri-implant Mucositis

Currently open trials in the same condition.

NCT07349095 — AI-Assisted Colorimetric Diagnosis of Peri-Implant Mucosal Erythema · NA · recruiting
NCT07140146 — Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment · NA · recruiting
NCT06645444 — Immediate Implant Placement With Different Materials of Customized Healing Abutment for Guiding Peri-implant Soft Tissue · NA · recruiting
NCT07047261 — Efficacy of a Xanthan-based Chlorhexidine Gel in the Treatment of Peri-implant Mucositis · NA · recruiting
NCT06364982 — Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease. · recruiting

Other Federico II University trials

Trials by the same sponsor.

NCT07437690 — Fall Prevention in Older Adults in an Italian Cohort · not yet recruiting
NCT07282132 — Evaluation of Real-World Data on Ropeginterferon Alfa-2b in Patients With Polycythemia Vera: Insights From a Multicenter · not yet recruiting
NCT07280286 — Incidence of Intrauterine Adhesions After Myomectomy With Intrauterine Anti-Adhesion Gel · NA · not yet recruiting
NCT07374861 — Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Bempedoic Acid in Italy · recruiting
NCT07314684 — GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05926297 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Federico II University
Last refreshed: 24 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05926297.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing