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NCT05925790: PERIPLO
Clinical Phenotypes in Pericarditis: IL-1RA Antibodies and suPAR Levels
trial testing IL1RA Antibody Assay in Pericarditis in 146 participants. Currently enrolling.
1 July 2025
Quick facts
| Lead sponsor | ASST Fatebenefratelli Sacco |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 146 |
| Start date | 1 July 2023 |
| Primary completion | 1 July 2025 |
| Estimated completion | 20 December 2025 |
| Sites | 9 locations across Italy, Germany |
Drugs / interventions tested
- IL1RA Antibody Assay
- suPAR Testing
Conditions studied
- Pericarditis — all drugs for Pericarditis →
Sponsor
ASST Fatebenefratelli Sacco — full company profile →
Who can join
Adults 18 to 90, any sex, with Pericarditis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to investigate the pathophysiology of recurrent pericarditis (RP) by testing for neutralizing autoantibodies against interleukin-1 receptor antagonist (IL-1RA) and measuring soluble urokinase plasminogen activator receptor (suPAR) levels. The hypothesis is that these tests will provide insights into both the inflammatory and non-inflammatory phenotypes of RP, shedding light on the underlying mechanisms. The study will assess the correlation between antibody levels, suPAR levels, and markers of cardiac damage and inflammation. Longitudinal testing during acute episodes and intercritical phases is also planned. The results may guide the use of anakinra, an IL-1 receptor antagonist, in specific clinical scenarios and optimize treatment strategies for RP.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Current Drug Treatment for Acute and Recurrent Pericarditis.
Bonaventura A, Santagata D, Vecchié A, Abbate A. · · 2025 · cited 1× · PMID 40119189 · DOI 10.1007/s40265-025-02169-x
Verify or expand the search:
- PubMed search for NCT05925790
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05925790 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by ASST Fatebenefratelli Sacco
- Last refreshed: 3 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05925790.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing