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NCT05925101
Basic and Applied Research on Extinction Bursts
NA trial testing Extinction-only condition in Problem Behavior in 40 participants. Currently enrolling.
1 March 2028
Quick facts
| Lead sponsor | Rutgers, The State University of New Jersey |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 7 July 2023 |
| Primary completion | 1 March 2028 |
| Estimated completion | 31 May 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Extinction-only condition
- Rate-drop condition
- Rate-hold condition
- Magnitude-drop condition
- Magnitude-hold condition
- Quality-drop condition
- Quality-hold condition
- Rate-drop/quality-increase condition
Conditions studied
- Problem Behavior — all drugs for Problem Behavior →
- Aggression — all drugs for Aggression →
- Self Injury — all drugs for Self Injury →
Sponsor
Rutgers, The State University of New Jersey
Who can join
Adults 3 to 17, any sex, with Problem Behavior or Aggression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Although highly effective, treatments like FCT include extinction, which can have adverse side effects. The extinction burst, an increase in the frequency or intensity of destructive behavior at the start of treatment, is the most common side effect of extinction, and can increase the risk of harm to the patient and others. The goal of the current study is to evaluate the prevalence of extinction bursts when various parameters of reinforcement (i.e., rate, magnitude, quality) are manipulated.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05925101
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05925101 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rutgers, The State University of New Jersey
- Last refreshed: 27 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05925101.
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