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NCT05924971: ASAPP
Acetylsalicylic Acid for Postpartum Preeclampsia: A Pilot Randomized Trial
Phase 2 trial testing Aspirin 81Mg Ec Tab in Preeclampsia Postpartum in 86 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | MemorialCare Health System |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 86 |
| Start date | 26 July 2023 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Aspirin 81Mg Ec Tab — full drug profile →
Conditions studied
- Preeclampsia Postpartum — all drugs for Preeclampsia Postpartum →
Sponsor
MemorialCare Health System — full company profile →
Who can join
18 and older, female only, with Preeclampsia Postpartum. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Reduction in sFlt-1
Time frame: 1 week postpartum
This outcome will determine the absolute change in sFlt-1, an anti-angiogenic protein implicated in the pathophysiology of preeclampsia.
Sponsor's own description
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05924971
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Aspirin 81Mg Ec Tab
Trials testing the same drug.
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- NCT06228820 — Aspirin Resistance in Trinidad. · Phase 2 · completed
- NCT05889468 — Postpartum ASA and NT-proBNP · Phase 4 · completed
- NCT05514847 — Low Dose Aspirin for Preterm Preeclampsia Preventionmg/day Dose in High-risk Patients · Phase 4 · active not recruiting
- NCT05009862 — The Impact of Factor Xa Inhibition on Thrombosis, Platelet Activation, and Endothelial Function in Peripheral Artery Dis · Phase 4 · completed
Other recruiting trials for Preeclampsia Postpartum
Currently open trials in the same condition.
- NCT07345845 — MR and Inflammation After Preeclampsia · EARLY_PHASE1 · active not recruiting
- NCT06749418 — Vascular Effects of High-Salt After Preeclampsia · EARLY_PHASE1 · recruiting
- NCT06373367 — Preeclampsia Educational Program Study (PrEPS) · NA · active not recruiting
- NCT05937841 — Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia · EARLY_PHASE1 · recruiting
- NCT05534932 — Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic Af · NA · active not recruiting
Other MemorialCare Health System trials
Trials by the same sponsor.
- NCT06373367 — Preeclampsia Educational Program Study (PrEPS) · NA · active not recruiting
- NCT06363929 — Continuous Glucose Monitoring in Neonatal Hyperinsulinism · terminated
- NCT05751863 — Analgesia-First Sedation in Trauma Patients · NA · recruiting
- NCT04199676 — Immediate Postpartum Glucose Tolerance Testing · recruiting
- NCT02715921 — Impact of Telerehabilitation Training on Pediatric Cystic Fibrosis Patients: An Exploratory Study · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05924971 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by MemorialCare Health System
- Last refreshed: 3 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05924971.
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