NCT05924399

PTSD Affect Labeling Study

Completed NA Last updated 29 June 2023

What this trial tests

NA trial testing Affect Labeling Training in Post-traumatic Stress Disorder in 119 participants. Completed in 9 October 2015.

Timeline

5 August 2014

Primary endpoint
9 October 2015

9 October 2015

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	119
Start date	5 August 2014
Primary completion	9 October 2015
Estimated completion	9 October 2015
Sites	1 location across United States

Drugs / interventions tested

• Affect Labeling Training

Conditions studied

• Post-traumatic Stress Disorder — all drugs for Post-traumatic Stress Disorder →
• Post-Traumatic Stress Disorder, Chronic — all drugs for Post-Traumatic Stress Disorder, Chronic →

Sponsor

University of California, Los Angeles

Who can join

Adults 18 to 45, any sex, with Post-traumatic Stress Disorder or Post-Traumatic Stress Disorder, Chronic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The overall goal of this study is to use fMRI and psychophysiological measures to investigate a novel strategy involving "Affect Labeling" for improving emotion regulation in PTSD that could lead to a new treatment regimen for PTSD.

Our project has two specific aims. First, the investigators aim to identify a novel neural target for possible PTSD intervention by verifying that RVLPFC-based inhibitory processing is impaired in PTSD. Second, the investigators will examine whether repeated practice with a simple cognitive-emotional task that requires inhibitory processing, namely, affect labeling, can strengthen the RVLPFC's ability to down-regulate emotional responses and physiological reactivity in PTSD and thereby form the basis of a novel treatment strategy to be developed in future studies. Secondary objectives are to examine the extent to which RVLPFC-based inhibitory impairments in PTSD are specific to trauma-relevant emotional processing (i.e., trauma-related distress) or extend to other types of inhibitory regulation in general, which would have implications for the future study of inhibitory-enhancement-based interventions for PTSD.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Affect labeling: a promising new neuroscience-based approach to treating combat-related PTSD in veterans.
   Burklund LJ, Davies CD, Niles A, Torre JB, et al · · 2024 · PMID 38911954 · DOI 10.3389/fpsyg.2024.1270424