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NCT05912374
Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs
NA trial testing standard Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB) in Cognitive Dysfunction in 50 participants. Completed in 12 December 2022.
12 December 2022
Quick facts
| Lead sponsor | University of Connecticut |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 50 |
| Start date | 7 September 2022 |
| Primary completion | 12 December 2022 |
| Estimated completion | 12 December 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- standard Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB)
- enhanced Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB)
Conditions studied
- Cognitive Dysfunction — all drugs for Cognitive Dysfunction →
Sponsor
University of Connecticut
Who can join
18 and older, any sex, with Cognitive Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this pilot work was to determine if the cognitive dysfunction accommodation strategies help patients retain/utilize more HIV prevention information and increase PrEP adherence. Fifty people who inject drugs (PWID) were prescribed PrEP and randomized to one of two conditions, Twenty-five PWID participated in a standard HIV prevention session and 25 other PWID participated in a HIV prevention session with the included accommodation strategies. At recruitment participants were asked to provide self-report of the screening form and cognitive functioning. The intervention consisted of a total of 5 sessions: 1 meeting to gain baseline information of participants and 4 intervention sessions. Participants completed the consent form, demographics, skills assessment, drug use behavior assessment, and HIV risk behavior assessment at the pre-interview meeting. Participants completed PrEP uptake assessments and skills assessments immediately following the intervention to compare the pre/post results between the two groups. All participants also completed an acceptability rating to help researchers determine the acceptability of the accommodation strategies used, at the end of the 4th session. The objective was to determine if the proposed accommodation strategies are feasible and efficacious at improving HIV prevention outcomes, including knowledge and skills. Information gleaned from this process will be used to refine the intervention approach for future testing and implementation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Testing the feasibility, acceptability, and preliminary efficacy of integrating accommodation strategies into an HIV prevention intervention for people who inject drugs with cognitive dysfunction.
Mistler CB, Shrestha R, Copenhaver MM. · · 2025 · PMID 39551147 · DOI 10.1016/j.josat.2024.209582
Verify or expand the search:
- PubMed search for NCT05912374
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05912374 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Connecticut
- Last refreshed: 22 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05912374.
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