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NCT05909410
Perception About Benefits and Risks Related to Combined Hormonal Contraceptives Use in Patients With Lynch Syndrome
trial testing Survey investigating the CHC use and patients' perception about the relationship between CHC and cancer, diseases and symptoms in Lynch Syndrome in 180 participants. Status unknown.
1 July 2023
Quick facts
| Lead sponsor | Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 180 |
| Start date | 1 July 2023 |
| Primary completion | 1 July 2023 |
| Estimated completion | 1 September 2023 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Survey investigating the CHC use and patients' perception about the relationship between CHC and cancer, diseases and symptoms
Conditions studied
- Lynch Syndrome — all drugs for Lynch Syndrome →
- Contraception — all drugs for Contraception →
Sponsor
Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia
Who can join
Adults 18 to 52, female only, with Lynch Syndrome or Contraception. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Combined hormonal contraceptives (CHCs), according to the opinion by The Manchester International Consensus Group, should be considered for women wishing contraception because also positively impact endometrial cancer and ovarian cancer risk. The awareness of the effects of hormonal therapies in women at high risk of developing endometrial cancer, colorectal, breast, or ovarian cancer, such as those affected by Lynch syndrome (LS), is currently limited, with few published studies addressing these populations. Making informed decisions about CHC use in this context necessitates careful consideration of individual cancer risk and the potential benefits and risks associated with CHC use. Accurate information regarding the oncological risks associated with CHC use is essential for facilitating shared decision-making between women and their healthcare providers in this patient population. This prospective study aims to evaluate the knowledge, attitudes, and beliefs of women with LS concerning CHCs and their potential effects on specific disease development and cancer risk, comparing them to the general population. By considering psychosocial factors and individual perceptions of cancer risk, this study seeks to contribute to informed decision-making, personalized counseling, and improved strategies for gynecologic cancer risk management in women with LS.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Perception about benefits and risks related to combined hormonal contraceptives use in women with Lynch syndrome.
Barra F, Perrone U, Ferrero S, Bogliolo S, et al · · 2024 · PMID 38920120 · DOI 10.1080/07853890.2024.2370568
Verify or expand the search:
- PubMed search for NCT05909410
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Lynch Syndrome
Currently open trials in the same condition.
- NCT07163403 — First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived Neopeptid · Phase 1 · recruiting
- NCT06582914 — Lynch Syndrome Integrative Epidemiology and Genetics · recruiting
- NCT06447961 — PSYLIVED: the Psychological Impacts of Living With an Inherited Colorectal Cancer Predisposition Syndrome · recruiting
- NCT05963191 — CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome · NA · recruiting
- NCT06712095 — Video Capsule Examination in Patients With Lynch Syndrome · NA · recruiting
Other Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia trials
Trials by the same sponsor.
- NCT05291624 — Ultrasonographic and Surgical Assessment of Endometriosis by AAGL 2021 Endometriosis Classification · unknown
- NCT04936386 — Knowledge and Perspective of Healthcare Professionals About Female Genital Mutation · completed
- NCT04395755 — Impact of COVID-19 on Psychological Status in Case of IVF Interrupted or Postponed · completed
- NCT04338945 — Impact of Pandemic COVID-19 on Surgical Specialities Residents in Italy · completed
- NCT04424771 — Post-traumatic Stress Disease in Health Workers During COVID-19 Pandemia · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05909410 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia
- Last refreshed: 18 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05909410.
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