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NCT05908929
PRF Therapy for Pocket Reduction
NA trial testing SRP and concomitant insertion of PRF membrane in Periodontal Pocket in 13 participants. Completed in 15 February 2023.
15 January 2023
Quick facts
| Lead sponsor | Federico II University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 13 |
| Start date | 15 September 2022 |
| Primary completion | 15 January 2023 |
| Estimated completion | 15 February 2023 |
| Sites | 2 locations across Italy |
Drugs / interventions tested
- SRP and concomitant insertion of PRF membrane
- SRP — full drug profile →
Conditions studied
- Periodontal Pocket — all drugs for Periodontal Pocket →
- Periodontitis — all drugs for Periodontitis →
Sponsor
Federico II University
Who can join
18 and older, any sex, with Periodontal Pocket or Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontal regenerative therapy has focused on various non-surgical and surgical treatment methods. Platelet-rich fibrin (PRF) has shown to possess multiple uses, including properties that promote healing of both soft and hard tissues. In the present study, we hypothesized that the addition of PRF into periodontal pockets, as an adjunct to conventional scaling and root planing (SRP), would enhance the outcomes of non-surgical periodontal therapy. This split-mouth randomized controlled clinical trial included 26 periodontal pocket sites in 13 patients with periodontitis. The pockets were randomly assigned as either test or control sites. In the test group, PRF was placed as an adjunct to SRP, while the control group received SRP alone. Probing pocket depths (PPD), clinical attachment levels (CAL), gingival recession (GR), plaque index (PI), and gingivitis index (GI) were measured at baseline and at six weeks. The wound healing index was measured during the six-week follow-up period.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Platelet-Rich Fibrin in Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial.
Parwani SR, Thakare KS, Kawadkar KP, Soni NJ, et al · · 2024 · cited 7× · PMID 38786533 · DOI 10.3390/dj12050135
Verify or expand the search:
- PubMed search for NCT05908929
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periodontal Pocket
Currently open trials in the same condition.
- NCT07375004 — Injectable PRF in Non-Surgical Periodontal Treatment · NA · active not recruiting
- NCT06522438 — Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment · NA · recruiting
- NCT06123000 — Modified Widman Flap vs Fibre Retention Osseous Resective Surgery · NA · recruiting
- NCT06982248 — The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment · Phase 2 · active not recruiting
- NCT06351982 — Treatment Of Shallow Periodontal Pockets 4-6mm Using AIRFLOW Prophylaxis Master Device With Erythritol vs Manual Scalers · NA · recruiting
Other Federico II University trials
Trials by the same sponsor.
- NCT07437690 — Fall Prevention in Older Adults in an Italian Cohort · not yet recruiting
- NCT07282132 — Evaluation of Real-World Data on Ropeginterferon Alfa-2b in Patients With Polycythemia Vera: Insights From a Multicenter · not yet recruiting
- NCT07280286 — Incidence of Intrauterine Adhesions After Myomectomy With Intrauterine Anti-Adhesion Gel · NA · not yet recruiting
- NCT07374861 — Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Bempedoic Acid in Italy · recruiting
- NCT07314684 — GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05908929 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Federico II University
- Last refreshed: 18 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05908929.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing