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NCT05905237

Measurement of Antioxidant Activity on Postoperative Inflammation in Patients Undergoing Ophthalmic Surgery

Completed Last updated 4 December 2024
What this trial tests

trial testing Cataract surgery, Femtosecond-LASIK, SMILE in Cataract in 132 participants. Completed in 28 July 2023.

Timeline
12 July 2022
Primary endpoint
28 July 2023
28 July 2023

Quick facts

Lead sponsorChang Gung Memorial Hospital
StatusCompleted
Study typeOBSERVATIONAL
Enrollment132
Start date12 July 2022
Primary completion28 July 2023
Estimated completion28 July 2023
Sites2 locations across Taiwan

Drugs / interventions tested

Conditions studied

Sponsor

Chang Gung Memorial Hospital

Who can join

20 and older, any sex, with Cataract or Myopia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This trial hypothesized that novel laser refractive surgery techniques (PRK, LASIK, SMILE) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing oxidative stress generated by the surgical procedure. It is also intended to verify whether the new laser technology is necessary for clinical use in groups with low antioxidant activity through the detection of antioxidant activity in the eyes of patients.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Differences in change of post-operative antioxidant levels between laser-assisted lenticule extraction and femtosecond laser in situ keratomileusis.
    Chen HC, Yang SF, Lee CY, Hsueh YJ, et al · · 2024 · cited 9× · PMID 38051678 · DOI 10.1111/jcmm.18069
  2. The effect of preoperative total antioxidant capacity on short-term outcomes after kerato-lenticule extraction surgery.
    Lee CY, Chen HC, Yang SF, Hsueh YJ, et al · · 2025 · cited 4× · PMID 40044702 · DOI 10.1038/s41598-025-91654-0
  3. The Relationship Between Concurrent Preoperative Dry Eye Disease and Ascorbic Acid Levels and the Outcomes of Kerato-Lenticule Extraction Surgery.
    Lee CY, Yang SF, Chen HC, Hsueh YJ, et al · · 2025 · cited 1× · PMID 40046397 · DOI 10.7759/cureus.78430
  4. The Effect of Preoperative Aqueous Total Antioxidant Capacity on the Postoperative Complications of Cataract Surgery.
    Lee CY, Yang SF, Chen HC, Hsueh YJ, et al · · 2025 · PMID 41167667 · DOI 10.21873/invivo.14133
  5. Postoperative Decline in Antioxidant Concentrations in Aqueous Humor: Comparison Between Femtosecond Laser-assisted Cataract Surgery and Conventional Cataract Surgery.
    Lee CY, Yang SF, Chen HC, Hsueh YJ, et al · · 2025 · PMID 40877159 · DOI 10.21873/invivo.14071

Verify or expand the search:

Other recruiting trials for Cataract

Currently open trials in the same condition.

Other Chang Gung Memorial Hospital trials

Trials by the same sponsor.

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Data sources for this page

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing