Last reviewed · How we verify
NCT05896319
Hyaluronic Acid Treatment of the Post-extraction Tooth Socket Healing in Subjects With Diabetes Mellitus Type 2
NA trial testing Hyaluronic acid gel in Diabetes Mellitus, Type 2 in 36 participants. Completed in 8 March 2023.
8 February 2023
Quick facts
| Lead sponsor | University of Turin, Italy |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | supportive care |
| Enrollment | 36 |
| Start date | 7 September 2022 |
| Primary completion | 8 February 2023 |
| Estimated completion | 8 March 2023 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Hyaluronic acid gel
Conditions studied
- Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
- Delayed Wound Healing — all drugs for Delayed Wound Healing →
- Tooth Extraction Status Nos — all drugs for Tooth Extraction Status Nos →
Sponsor
University of Turin, Italy
Who can join
18 and older, any sex, with Diabetes Mellitus, Type 2 or Delayed Wound Healing. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the present split-mouth study was to investigate the effect of Hyaluronic Acid (HA) in improving the post-extraction tooth socket healing in subjects with diabetes mellitus type 2. The null hypothesis was that HA can significantly improve the post extractive healing of diabetic patients compared with no treatment. 36 patients with diabetes mellitus type 2 requiring bilateral extraction of the homologous, not included, teeth were enrolled. After the extractions carried out in the same appointment, following the split-mouth design of the study, one site was randomly assigned to the test (T) group, while the other one was assigned to the control group (C). T group included: Post-operative application of Hyaluronic acid gels 3 times per day C group included: no treatment. Patients were then followed after 3, 7,14 and 21 days and the healing of each socket was evaluated and compared between the 2 groups.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Hyaluronic Acid Treatment of Post-Extraction Tooth Socket Healing in Subjects with Diabetes Mellitus Type 2: A Randomized Split-Mouth Controlled Study.
Ruggiero T, Carossa M, Camisassa D, Bezzi M, et al · · 2024 · cited 2× · PMID 38256586 · DOI 10.3390/jcm13020452 -
Combining Hyaluronic Acid and Amino Acids for Improved Healing of Post-Extraction Tooth Socket in Type 2 Diabetes Mellitus Subjects: A Randomized Clinical Trial.
Ruggiero T, Camisassa D, Bezzi M, Cogno E, et al · · 2026 · PMID 41744941 · DOI 10.3390/dj14020103
Verify or expand the search:
- PubMed search for NCT05896319
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Hyaluronic acid gel
Trials testing the same drug.
- NCT05937100 — New Vital Pulpotomy Medications in Primary Molars · NA · active not recruiting
- NCT05953896 — Efficacy of HA Gel Injection Versus Multilayer (L-PRF) in the Interdental Papilla Reconstruction · NA · completed
- NCT04869306 — Effect of Hyaluronic Acid on Tissue Healing After Removal of Impacted Mandibular Third Molars (LM3) · NA · unknown
- NCT04853589 — Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis · NA · unknown
- NCT04070729 — Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy · NA · unknown
Other recruiting trials for Diabetes Mellitus, Type 2
Currently open trials in the same condition.
- NCT07415954 — A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 · Phase 2 · recruiting
- NCT07532863 — A Real-world Study to Investigate Cardiovascular Risk Profile Among Newly Diagnosed Type 2 Diabetes Mellitus (T2DM) Part · recruiting
- NCT07336329 — Continuous Glucose Monitoring in Non-Insulin Treated Type 2 Diabetes: Continuous vs. Periodic Use · NA · recruiting
- NCT07242469 — A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006) · Phase 1 · recruiting
- NCT07444203 — Transformative Research in Diabetic Nephropathy 2.0 · recruiting
Other University of Turin, Italy trials
Trials by the same sponsor.
- NCT06493188 — Low VS High-fidelity Interprofessional Simulation for ABG Skills Acquisition · NA · not yet recruiting
- NCT07418489 — Biotics Intervention Oriented to Rescue From Environmental Pollution Inflammatory Responses · NA · enrolling by invitation
- NCT07311291 — The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Microsurgery. · NA · completed
- NCT06904963 — Efficacy of Oral Hygiene Instructions Carried Out Using an Intra-oral Scanner · NA · completed
- NCT07047261 — Efficacy of a Xanthan-based Chlorhexidine Gel in the Treatment of Peri-implant Mucositis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05896319 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Turin, Italy
- Last refreshed: 9 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05896319.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing